BAIT
IGF1
IGF-I, IGF1A, IGFI
insulin-like growth factor 1 (somatomedin C)
GO Process (50)
GO Function (5)
GO Component (5)
Gene Ontology Biological Process
- DNA replication [TAS]
- Ras protein signal transduction [TAS]
- blood coagulation [TAS]
- bone mineralization involved in bone maturation [IDA]
- cell activation [IDA]
- cellular component movement [TAS]
- cellular protein metabolic process [TAS]
- glycolate metabolic process [TAS]
- muscle hypertrophy [IMP]
- muscle organ development [TAS]
- myoblast differentiation [IDA]
- myoblast proliferation [IDA]
- myotube cell development [IDA]
- negative regulation of extrinsic apoptotic signaling pathway [IDA]
- negative regulation of oocyte development [IMP]
- negative regulation of release of cytochrome c from mitochondria [ISS]
- negative regulation of smooth muscle cell apoptotic process [IDA]
- phosphatidylinositol-mediated signaling [IDA]
- platelet activation [TAS]
- platelet degranulation [TAS]
- positive regulation of DNA binding [IDA]
- positive regulation of DNA replication [IDA, ISS]
- positive regulation of MAPK cascade [IDA]
- positive regulation of Ras protein signal transduction [IDA]
- positive regulation of activated T cell proliferation [IDA]
- positive regulation of calcineurin-NFAT signaling cascade [IDA]
- positive regulation of cardiac muscle hypertrophy [IDA]
- positive regulation of cell proliferation [IDA]
- positive regulation of epithelial cell proliferation [IDA]
- positive regulation of fibroblast proliferation [IDA]
- positive regulation of glucose import [IDA]
- positive regulation of glycogen biosynthetic process [IDA]
- positive regulation of glycolytic process [IDA]
- positive regulation of insulin-like growth factor receptor signaling pathway [IDA]
- positive regulation of mitosis [IDA]
- positive regulation of osteoblast differentiation [IDA]
- positive regulation of peptidyl-tyrosine phosphorylation [IDA]
- positive regulation of phosphatidylinositol 3-kinase signaling [IDA]
- positive regulation of protein import into nucleus, translocation [IDA]
- positive regulation of smooth muscle cell migration [IDA]
- positive regulation of smooth muscle cell proliferation [IDA]
- positive regulation of transcription from RNA polymerase II promoter [IDA]
- positive regulation of transcription, DNA-templated [IDA]
- positive regulation of tyrosine phosphorylation of Stat5 protein [IDA]
- proteoglycan biosynthetic process [IDA]
- regulation of gene expression [IMP]
- regulation of multicellular organism growth [IEP]
- signal transduction [TAS]
- skeletal muscle satellite cell maintenance involved in skeletal muscle regeneration [IDA]
- skeletal system development [TAS]
Gene Ontology Molecular Function
Gene Ontology Cellular Component
Homo sapiens
PREY
IGFBP5
IBP5
insulin-like growth factor binding protein 5
GO Process (9)
GO Function (4)
GO Component (3)
Gene Ontology Biological Process
- cellular protein metabolic process [TAS]
- cellular response to cAMP [IDA]
- cellular response to organic cyclic compound [IDA]
- negative regulation of cell migration [IDA]
- negative regulation of insulin-like growth factor receptor signaling pathway [IDA]
- negative regulation of smooth muscle cell migration [IDA]
- negative regulation of smooth muscle cell proliferation [IDA]
- negative regulation of translation [IDA]
- signal transduction [NAS]
Gene Ontology Molecular Function
Gene Ontology Cellular Component
Homo sapiens
Reconstituted Complex
An interaction is detected between purified proteins in vitro.
Publication
Insulin-like growth factor (IGF)-binding protein 5 forms an alternative ternary complex with IGFs and the acid-labile subunit.
Up to 90% of circulating insulin-like growth factors (IGF-I and IGF-II) are carried in heterotrimeric complexes with a binding protein (IGFBP) and a liver-derived glycoprotein known as the acid-labile subunit. IGFBP-3 is considered unique among the six well characterized IGFBPs in its ability to complex with the acid-labile subunit. However, a basic carboxyl-terminal domain of IGFBP-3, known to be involved ... [more]
J. Biol. Chem. Mar. 13, 1998; 273(11);6074-9 [Pubmed: 9497324]
Throughput
- Low Throughput
Curated By
- BioGRID