ATG16L1
Gene Ontology Biological Process
Gene Ontology Molecular Function
Gene Ontology Cellular Component
ULK1
Gene Ontology Biological Process
- Ras protein signal transduction [IDA]
- autophagic vacuole assembly [IMP]
- axon extension [IMP]
- axonogenesis [IDA]
- cellular response to nutrient levels [IDA]
- cerebellar granule cell differentiation [IMP]
- negative regulation of collateral sprouting [IMP]
- neuron projection development [IMP, ISO]
- neuron projection regeneration [ISO]
- positive regulation of autophagy [IMP]
- positive regulation of macroautophagy [ISO]
- protein autophosphorylation [IDA, ISO]
- protein localization [ISO]
- radial glia guided migration of cerebellar granule cell [IMP]
- receptor internalization [IMP]
- regulation of autophagy [IMP, ISO]
- regulation of neurotrophin TRK receptor signaling pathway [IMP]
- response to starvation [IDA]
Gene Ontology Molecular Function
Gene Ontology Cellular Component
- ATG1/UKL1 signaling complex [IBA]
- ULK1-ATG13-FIP200 complex [IPI, ISO]
- autophagic vacuole [ISO]
- cytoplasm [IDA]
- cytoplasmic vesicle membrane [IDA]
- cytosol [IDA, ISO]
- extrinsic component of autophagic vacuole membrane [ISO]
- extrinsic component of omegasome membrane [ISO]
- extrinsic component of pre-autophagosomal structure membrane [ISO]
- membrane [IDA]
- neuron projection [IDA]
- neuronal cell body [IDA]
- pre-autophagosomal structure [IDA]
- pre-autophagosomal structure membrane [IDA, ISO]
Co-localization
Interaction inferred from two proteins that co-localize in the cell by indirect immunofluorescence only when in addition, if one gene is deleted, the other protein becomes mis-localized. Also includes co-dependent association of proteins with promoter DNA in chromatin immunoprecipitation experiments.
Publication
FIP200 regulates targeting of Atg16L1 to the isolation membrane.
Autophagosome formation is a dynamic process that is strictly controlled by autophagy-related (Atg) proteins. However, how these Atg proteins are recruited to the autophagosome formation site or autophagic membranes remains poorly understood. Here, we found that FIP200, which is involved in proximal events, directly interacts with Atg16L1, one of the downstream Atg factors, in an Atg14- and phosphatidylinositol 3-kinase-independent manner. ... [more]
Throughput
- Low Throughput
Curated By
- BioGRID