Interaction inferred from two proteins that co-localize in the cell by indirect immunofluorescence only when in addition, if one gene is deleted, the other protein becomes mis-localized. Also includes co-dependent association of proteins with promoter DNA in chromatin immunoprecipitation experiments.

Publication

FIP200 regulates targeting of Atg16L1 to the isolation membrane.

Nishimura T, Kaizuka T, Cadwell K, Sahani MH, Saitoh T, Akira S, Virgin HW, Mizushima N

Autophagosome formation is a dynamic process that is strictly controlled by autophagy-related (Atg) proteins. However, how these Atg proteins are recruited to the autophagosome formation site or autophagic membranes remains poorly understood. Here, we found that FIP200, which is involved in proximal events, directly interacts with Atg16L1, one of the downstream Atg factors, in an Atg14- and phosphatidylinositol 3-kinase-independent manner. ... [more]

EMBO Rep. Mar. 01, 2013; 14(3);284-91 [Pubmed: 23392225]

Throughput

Low Throughput

Curated By

BioGRID

Interaction Summary

ATG16L1

Gene Ontology Biological Process

Gene Ontology Molecular Function

identical protein binding [ISO]protein binding [IPI]

Gene Ontology Cellular Component

ATG9A