GRM5
Gene Ontology Biological Process
Gene Ontology Molecular Function
Gene Ontology Cellular Component
GRIN1
Gene Ontology Biological Process
- calcium ion homeostasis [ISS]
- calcium ion transmembrane transport [IDA]
- cation transport [IDA]
- ion transmembrane transport [IBA]
- ionotropic glutamate receptor signaling pathway [IBA, ISS]
- positive regulation of excitatory postsynaptic membrane potential [ISS]
- positive regulation of transcription from RNA polymerase II promoter [ISS]
- propylene metabolic process [ISS]
- regulation of excitatory postsynaptic membrane potential [ISS]
- regulation of membrane potential [IDA]
- response to ethanol [IDA]
- synaptic transmission [TAS]
- synaptic transmission, glutamatergic [IBA]
- visual learning [ISS]
Gene Ontology Molecular Function
Gene Ontology Cellular Component
- N-methyl-D-aspartate selective glutamate receptor complex [IDA]
- cell surface [ISS]
- dendrite [IDA]
- dendritic spine [ISS]
- excitatory synapse [ISS]
- integral component of plasma membrane [IDA]
- neuron projection [ISS]
- plasma membrane [TAS]
- postsynaptic density [ISS]
- postsynaptic membrane [IBA, ISS]
- synapse [ISS]
- synaptic cleft [ISS]
- synaptic vesicle [ISS]
- terminal bouton [ISS]
Affinity Capture-Western
An interaction is inferred when a bait protein is affinity captured from cell extracts by either polyclonal antibody or epitope tag and the associated interaction partner identified by Western blot with a specific polyclonal antibody or second epitope tag. This category is also used if an interacting protein is visualized directly by dye stain or radioactivity. Note that this differs from any co-purification experiment involving affinity capture in that the co-purification experiment involves at least one extra purification step to get rid of potential contaminating proteins.
Publication
mGluR5 hypofunction is integral to glutamatergic dysregulation in schizophrenia.
Multiple lines of evidence point to glutamatergic signaling in the postsynaptic density (PSD) as a pathophysiologic mechanism in schizophrenia. Integral to PSD glutamatergic signaling is reciprocal interplay between GluN and mGluR5 signaling. We examined agonist-induced mGluR5 signaling in the postmortem dorsolateral prefrontal cortex (DLPFC) derived from 17 patients and age-matched and sex-matched controls. The patient group showed a striking reduction ... [more]
Throughput
- Low Throughput
Curated By
- BioGRID