BAIT
UBR5
DD5, EDD, EDD1, HYD
ubiquitin protein ligase E3 component n-recognin 5
GO Process (11)
GO Function (3)
GO Component (4)
Gene Ontology Biological Process
- cell proliferation [TAS]
- cellular response to DNA damage stimulus [IDA, IMP]
- negative regulation of double-strand break repair [IMP]
- negative regulation of histone H2A K63-linked ubiquitination [IMP]
- positive regulation of canonical Wnt signaling pathway [IMP]
- positive regulation of catenin import into nucleus [IMP]
- positive regulation of protein import into nucleus, translocation [IMP]
- progesterone receptor signaling pathway [IDA]
- protein polyubiquitination [IDA]
- protein ubiquitination involved in ubiquitin-dependent protein catabolic process [IBA]
- ubiquitin-dependent protein catabolic process [TAS]
Gene Ontology Molecular Function
Homo sapiens
PREY
TCP1
CCT-alpha, CCT1, CCTa, D6S230E, TCP-1-alpha
t-complex 1
GO Process (4)
GO Function (3)
GO Component (4)
Gene Ontology Biological Process
Gene Ontology Molecular Function
Gene Ontology Cellular Component
Homo sapiens
Affinity Capture-MS
An interaction is inferred when a bait protein is affinity captured from cell extracts by either polyclonal antibody or epitope tag and the associated interaction partner is identified by mass spectrometric methods.
Publication
E3 Ubiquitin Ligase UBR5 Promotes the Metastasis of Pancreatic Cancer via Destabilizing F-Actin Capping Protein CAPZA1.
The ubiquitin-proteasome system (UPS) is a regulated mechanism of intracellular protein degradation and turnover, and its dysfunction is associated with various diseases including cancer. UBR5, an E3 ubiquitin ligase, is emerging as an important regulator of the UPS in cancers, but its role in pancreatic cancer is poorly understood. Here, we show that UBR5 is significantly upregulated in pancreatic cancer ... [more]
Front Oncol Mar. 30, 2021; 11();634167 [Pubmed: 33777788]
Throughput
- High Throughput
Curated By
- BioGRID