Publication

Matrix-screening reveals a vast potential for direct protein-protein interactions among RNA binding proteins.

Lang B, Yang JS, Garriga-Canut M, Speroni S, Aschern M, Gili M, Hoffmann T, Tartaglia GG, Maurer SP

RNA-binding proteins (RBPs) are crucial factors of post-transcriptional gene regulation and their modes of action are intensely investigated. At the center of attention are RNA motifs that guide where RBPs bind. However, sequence motifs are often poor predictors of RBP-RNA interactions in vivo. It is hence believed that many RBPs recognize RNAs as complexes, to increase specificity and regulatory possibilities. ... [more]

Throughput

• High Throughput

Additional Notes

• Included protein pairs with sumIS score >= 7.1

Curated By

• BioGRID