BAIT

CDK1

CDC2, CDC28A, P34CDC2
cyclin-dependent kinase 1
GO Process (46)
GO Function (5)
GO Component (11)

Gene Ontology Biological Process

Homo sapiens
PREY

RAP1GAP

RAP1GA1, RAP1GAP1, RAP1GAPII, RAPGAP, RP11-63N8.1
RAP1 GTPase activating protein
Homo sapiens

Biochemical Activity (Phosphorylation)

An interaction is inferred from the biochemical effect of one protein upon another, for example, GTP-GDP exchange activity or phosphorylation of a substrate by a kinase. The bait protein executes the activity on the substrate hit protein. A Modification value is recorded for interactions of this type with the possible values Phosphorylation, Ubiquitination, Sumoylation, Dephosphorylation, Methylation, Prenylation, Acetylation, Deubiquitination, Proteolytic Processing, Glucosylation, Nedd(Rub1)ylation, Deacetylation, No Modification, Demethylation.

Publication

Phosphorylation of Rap1GAP during the cell cycle.

Janoueix-Lerosey I, Fontenay M, Tobelem G, Tavitian A, Polakis P, de Gunzburg J

Rap1GAP (for Rap1 GTPase Activating Protein) is an 89 kD protein that highly stimulates the intrinsic GTPase activity of the small GTP binding protein Rap1. It has been shown that Rap1GAP is phosphorylated in vitro by purified p34cdc2 kinase, which regulates the G2/M transition of the cell cycle. In this work, we have studied the phosphorylation of Rap1GAP during the ... [more]

Biochem Biophys Res Commun Jul. 29, 1994; 202(2);967-75 [Pubmed: 8048970]

Throughput

  • Low Throughput

Curated By

  • BioGRID