BAIT
RBBP6
P2P-R, PACT, RBQ-1, SNAMA, My038
retinoblastoma binding protein 6
GO Process (1)
GO Function (3)
GO Component (1)
Gene Ontology Biological Process
Gene Ontology Molecular Function
Gene Ontology Cellular Component
Homo sapiens
PREY
RPS14
EMTB, S14, PRO2640
ribosomal protein S14
GO Process (18)
GO Function (4)
GO Component (7)
Gene Ontology Biological Process
- RNA metabolic process [TAS]
- SRP-dependent cotranslational protein targeting to membrane [TAS]
- cellular protein metabolic process [TAS]
- erythrocyte differentiation [IMP]
- gene expression [TAS]
- mRNA metabolic process [TAS]
- maturation of SSU-rRNA [ISS]
- negative regulation of transcription from RNA polymerase II promoter [IDA]
- nuclear-transcribed mRNA catabolic process, nonsense-mediated decay [TAS]
- regulation of translation [IMP]
- ribosomal small subunit assembly [IMP, ISS]
- translation [IC, IMP, TAS]
- translational elongation [TAS]
- translational initiation [TAS]
- translational termination [TAS]
- viral life cycle [TAS]
- viral process [TAS]
- viral transcription [TAS]
Gene Ontology Molecular Function
Gene Ontology Cellular Component
Homo sapiens
Two-hybrid
Bait protein expressed as a DNA binding domain (DBD) fusion and prey expressed as a transcriptional activation domain (TAD) fusion and interaction measured by reporter gene activation.
Publication
RBBP6 interacts with multifunctional protein YB-1 through its RING finger domain, leading to ubiquitination and proteosomal degradation of YB-1.
RBBP6 (retinoblastoma binding protein 6) is a 250-kDa multifunctional protein that interacts with both p53 and pRb and has been implicated in mRNA processing. It has also been identified as a putative E3 ubiquitin ligase due to the presence of a RING finger domain, although no substrate has been identified up to now. Using the RING finger domain as bait ... [more]
J. Mol. Biol. Dec. 26, 2008; 384(4);908-16 [Pubmed: 18851979]
Throughput
- Low Throughput
Curated By
- BioGRID