BAIT
ADR1
DNA-binding transcription factor ADR1, L000000050, YDR216W
Carbon source-responsive zinc-finger transcription factor; required for transcription of the glucose-repressed gene ADH2, of peroxisomal protein genes, and of genes required for ethanol, glycerol, and fatty acid utilization
GO Process (10)
GO Function (7)
GO Component (2)
Gene Ontology Biological Process
- cellular response to oleic acid [IPI]
- chromatin organization [IDA]
- chromatin organization involved in regulation of transcription [IGI, IMP, IPI]
- negative regulation of chromatin silencing [IDA]
- peroxisome organization [IMP]
- positive regulation of ethanol catabolic process by positive regulation of transcription from RNA polymerase II promoter [IMP]
- positive regulation of fatty acid beta-oxidation by positive regulation of transcription from RNA polymerase II promoter [IMP]
- positive regulation of peroxisome organization by positive regulation of transcription from RNA polymerase II promoter [IMP]
- positive regulation of transcription from RNA polymerase II promoter by oleic acid [IMP]
- positive regulation of transcription from RNA polymerase II promoter in response to ethanol [IMP]
Gene Ontology Molecular Function- RNA polymerase II activating transcription factor binding [IPI]
- RNA polymerase II core promoter proximal region sequence-specific DNA binding [IDA]
- RNA polymerase II core promoter proximal region sequence-specific DNA binding transcription factor activity [IDA]
- RNA polymerase II transcription factor binding transcription factor activity involved in positive regulation of transcription [IPI]
- TFIIB-class transcription factor binding [IDA]
- TFIID-class transcription factor binding [IDA]
- sequence-specific DNA binding [IDA]
- RNA polymerase II activating transcription factor binding [IPI]
- RNA polymerase II core promoter proximal region sequence-specific DNA binding [IDA]
- RNA polymerase II core promoter proximal region sequence-specific DNA binding transcription factor activity [IDA]
- RNA polymerase II transcription factor binding transcription factor activity involved in positive regulation of transcription [IPI]
- TFIIB-class transcription factor binding [IDA]
- TFIID-class transcription factor binding [IDA]
- sequence-specific DNA binding [IDA]
Saccharomyces cerevisiae (S288c)
PREY
MNN10
BED1, REC41, SLC2, L000002793, L000002853, YDR245W
Subunit of a Golgi mannosyltransferase complex; complex mediates elongation of the polysaccharide mannan backbone; membrane protein of the mannosyltransferase family; other members of the complex are Anp1p, Mnn9p, Mnn11p, and Hoc1p
GO Process (3)
GO Function (1)
GO Component (1)
Gene Ontology Biological Process
Gene Ontology Molecular Function
Gene Ontology Cellular Component
Saccharomyces cerevisiae (S288c)
Negative Genetic
Mutations/deletions in separate genes, each of which alone causes a minimal phenotype, but when combined in the same cell results in a more severe fitness defect or lethality under a given condition. This term is reserved for high or low throughput studies with scores.
Publication
Functional organization of the S. cerevisiae phosphorylation network.
Reversible protein phosphorylation is a signaling mechanism involved in all cellular processes. To create a systems view of the signaling apparatus in budding yeast, we generated an epistatic miniarray profile (E-MAP) comprised of 100,000 pairwise, quantitative genetic interactions, including virtually all protein and small-molecule kinases and phosphatases as well as key cellular regulators. Quantitative genetic interaction mapping reveals factors working ... [more]
Cell Mar. 06, 2009; 136(5);952-63 [Pubmed: 19269370]
Quantitative Score
- -2.919345 [SGA Score]
Throughput
- High Throughput
Ontology Terms
- phenotype: colony size (APO:0000063)
Additional Notes
- An Epistatic MiniArray Profile (E-MAP) analysis was used to quantitatively score genetic interactions based on fitness defects estimated from the colony size of double versus single mutants. Genetic interactions were considered significant if they had an S score > 2.0 for positive interactions (suppression) and S score < -2.5 for negative interactions (synthetic sick/lethality).
Curated By
- BioGRID