BAIT
SDP1
mitogen-activated protein kinase tyrosine protein phosphatase SDP1, L000004339, YIL113W
Stress-inducible dual-specificity MAP kinase phosphatase; negatively regulates Slt2p MAP kinase by direct dephosphorylation, diffuse localization under normal conditions shifts to punctate localization after heat shock; SDP1 has a paralog, MSG5, that arose from the whole genome duplication
GO Process (4)
GO Function (2)
GO Component (3)
Gene Ontology Biological Process
- MAPK cascade involved in cell wall organization or biogenesis [IGI]
- adaptation of signaling pathway by response to pheromone involved in conjugation with cellular fusion [IBA]
- inactivation of MAPK activity involved in cell wall organization or biogenesis [IMP]
- regulation of pheromone-dependent signal transduction involved in conjugation with cellular fusion [IBA]
Gene Ontology Molecular Function
Saccharomyces cerevisiae (S288c)
PREY
PPA2
IPP2, inorganic diphosphatase PPA2, L000001469, YMR267W
Mitochondrial inorganic pyrophosphatase; required for mitochondrial function and possibly involved in energy generation from inorganic pyrophosphate
GO Process (1)
GO Function (1)
GO Component (1)
Gene Ontology Biological Process
Gene Ontology Molecular Function
Gene Ontology Cellular Component
- mitochondrion [IDA, IMP]
Saccharomyces cerevisiae (S288c)
Negative Genetic
Mutations/deletions in separate genes, each of which alone causes a minimal phenotype, but when combined in the same cell results in a more severe fitness defect or lethality under a given condition. This term is reserved for high or low throughput studies with scores.
Publication
Functional organization of the S. cerevisiae phosphorylation network.
Reversible protein phosphorylation is a signaling mechanism involved in all cellular processes. To create a systems view of the signaling apparatus in budding yeast, we generated an epistatic miniarray profile (E-MAP) comprised of 100,000 pairwise, quantitative genetic interactions, including virtually all protein and small-molecule kinases and phosphatases as well as key cellular regulators. Quantitative genetic interaction mapping reveals factors working ... [more]
Cell Mar. 06, 2009; 136(5);952-63 [Pubmed: 19269370]
Quantitative Score
- -4.852472 [SGA Score]
Throughput
- High Throughput
Ontology Terms
- phenotype: colony size (APO:0000063)
Additional Notes
- An Epistatic MiniArray Profile (E-MAP) analysis was used to quantitatively score genetic interactions based on fitness defects estimated from the colony size of double versus single mutants. Genetic interactions were considered significant if they had an S score > 2.0 for positive interactions (suppression) and S score < -2.5 for negative interactions (synthetic sick/lethality).
Curated By
- BioGRID