BAIT
PAM
PAL, PHM
peptidylglycine alpha-amidating monooxygenase
GO Process (1)
GO Function (4)
GO Component (2)
Gene Ontology Biological Process
Gene Ontology Molecular Function
Gene Ontology Cellular Component
Homo sapiens
PREY
KALRN
ARHGEF24, CHD5, CHDS5, DUET, DUO, HAPIP, TRAD, RP11-71H17.7
kalirin, RhoGEF kinase
GO Process (10)
GO Function (2)
GO Component (3)
Gene Ontology Biological Process
- apoptotic signaling pathway [TAS]
- intracellular signal transduction [ISS]
- nervous system development [ISS]
- neurotrophin TRK receptor signaling pathway [TAS]
- positive regulation of GTPase activity [TAS]
- positive regulation of apoptotic process [TAS]
- regulation of small GTPase mediated signal transduction [TAS]
- signal transduction [TAS]
- small GTPase mediated signal transduction [TAS]
- vesicle-mediated transport [TAS]
Gene Ontology Molecular Function
Gene Ontology Cellular Component
Homo sapiens
Two-hybrid
Bait protein expressed as a DNA binding domain (DBD) fusion and prey expressed as a transcriptional activation domain (TAD) fusion and interaction measured by reporter gene activation.
Publication
Kalirin, a cytosolic protein with spectrin-like and GDP/GTP exchange factor-like domains that interacts with peptidylglycine alpha-amidating monooxygenase, an integral membrane peptide-processing enzyme.
Although the integral membrane proteins that catalyze steps in the biosynthesis of neuroendocrine peptides are known to contain routing information in their cytosolic domains, the proteins recognizing this routing information are not known. Using the yeast two-hybrid system, we previously identified P-CIP10 as a protein interacting with the cytosolic routing determinants of peptidylglycine alpha-amidating monooxygenase (PAM). P-CIP10 is a 217-kDa ... [more]
J. Biol. Chem. May. 09, 1997; 272(19);12667-75 [Pubmed: 9139723]
Throughput
- Low Throughput
Related interactions
Curated By
- BioGRID