BAIT
HRAS
C-BAS/HAS, C-H-RAS, C-HA-RAS1, CTLO, H-RASIDX, HAMSV, HRAS1, RASH1, p21ras
Harvey rat sarcoma viral oncogene homolog
GO Process (39)
GO Function (3)
GO Component (4)
Gene Ontology Biological Process
- Fc-epsilon receptor signaling pathway [TAS]
- MAPK cascade [TAS]
- Ras protein signal transduction [IDA, TAS]
- activation of MAPKK activity [TAS]
- axon guidance [TAS]
- blood coagulation [TAS]
- cell cycle arrest [IDA, IMP]
- cell surface receptor signaling pathway [TAS]
- cellular senescence [IDA]
- chemotaxis [TAS]
- epidermal growth factor receptor signaling pathway [TAS]
- fibroblast growth factor receptor signaling pathway [TAS]
- innate immune response [TAS]
- insulin receptor signaling pathway [TAS]
- leukocyte migration [TAS]
- mitotic cell cycle checkpoint [IDA]
- negative regulation of Rho GTPase activity [IDA]
- negative regulation of cell proliferation [IDA]
- negative regulation of gene expression [IDA]
- neurotrophin TRK receptor signaling pathway [TAS]
- organ morphogenesis [TAS]
- positive regulation of DNA replication [IDA]
- positive regulation of ERK1 and ERK2 cascade [IDA]
- positive regulation of JNK cascade [IDA]
- positive regulation of MAP kinase activity [IDA]
- positive regulation of MAPK cascade [IDA]
- positive regulation of Rac GTPase activity [IDA]
- positive regulation of actin cytoskeleton reorganization [IDA]
- positive regulation of cell migration [IDA]
- positive regulation of cell proliferation [IDA]
- positive regulation of epithelial cell proliferation [IMP]
- positive regulation of miRNA metabolic process [IDA]
- positive regulation of protein phosphorylation [IDA]
- positive regulation of ruffle assembly [IDA]
- positive regulation of transcription from RNA polymerase II promoter [IDA]
- positive regulation of wound healing [IDA]
- signal transduction [NAS]
- small GTPase mediated signal transduction [TAS]
- synaptic transmission [TAS]
Gene Ontology Molecular Function
Gene Ontology Cellular Component
Homo sapiens
PREY
SNRPE
B-raf, HYPT11, SME, Sm-E
small nuclear ribonucleoprotein polypeptide E
GO Process (12)
GO Function (1)
GO Component (18)
Gene Ontology Biological Process
- RNA metabolic process [TAS]
- RNA splicing [TAS]
- gene expression [TAS]
- hair cycle [IMP]
- histone mRNA metabolic process [TAS]
- mRNA 3'-end processing [TAS]
- mRNA splicing, via spliceosome [IC, TAS]
- ncRNA metabolic process [TAS]
- spliceosomal complex assembly [NAS]
- spliceosomal snRNP assembly [IDA, TAS]
- termination of RNA polymerase II transcription [TAS]
- transcription from RNA polymerase II promoter [TAS]
Gene Ontology Molecular Function
Gene Ontology Cellular Component
- SMN-Sm protein complex [IDA]
- U1 snRNP [IDA]
- U12-type spliceosomal complex [IDA]
- U2 snRNP [IBA]
- U4 snRNP [IDA]
- U4/U6 x U5 tri-snRNP complex [IBA]
- U5 snRNP [IBA]
- U7 snRNP [IDA]
- catalytic step 2 spliceosome [IDA]
- cytosol [IDA, TAS]
- extracellular vesicular exosome [IDA]
- methylosome [IDA]
- nucleoplasm [TAS]
- nucleus [IDA]
- pICln-Sm protein complex [IDA]
- precatalytic spliceosome [IBA]
- small nuclear ribonucleoprotein complex [NAS]
- spliceosomal complex [NAS]
Homo sapiens
Two-hybrid
Bait protein expressed as a DNA binding domain (DBD) fusion and prey expressed as a transcriptional activation domain (TAD) fusion and interaction measured by reporter gene activation.
Publication
Interaction of activated Ras with Raf-1 alone may be sufficient for transformation of rat2 cells.
v-H-ras effector mutants have been assessed for transforming activity and for the ability of the encoded proteins to interact with Raf-1-, B-Raf-, byr2-, ralGDS-, and CDC25-encoded proteins in the yeast two-hybrid system. Transformation was assessed in rat2 cells as well as in a mutant cell line, rv68BUR, that affords a more sensitive transformation assay. Selected mutant Ras proteins were also ... [more]
Mol. Cell. Biol. Jun. 01, 1997; 17(6);3047-55 [Pubmed: 9154803]
Throughput
- Low Throughput
Related interactions
| Interaction | Experimental Evidence Code | Dataset | Throughput | Score | Curated By | Notes |
|---|---|---|---|---|---|---|
| SNRPE HRAS | Reconstituted Complex Reconstituted Complex An interaction is detected between purified proteins in vitro. | Low | - | BioGRID | - |
Curated By
- BioGRID