IL1RAP
Gene Ontology Biological Process
Gene Ontology Molecular Function
IRAK1
Gene Ontology Biological Process
- JNK cascade [ISO]
- activation of NF-kappaB-inducing kinase activity [ISO]
- cellular response to heat [ISO]
- cytokine-mediated signaling pathway [IDA, ISO]
- interleukin-1-mediated signaling pathway [IDA, ISO]
- lipopolysaccharide-mediated signaling pathway [IDA, ISO]
- negative regulation of NF-kappaB transcription factor activity [ISO]
- negative regulation of cholesterol efflux [IMP]
- negative regulation of transcription, DNA-templated [IMP]
- positive regulation of I-kappaB kinase/NF-kappaB signaling [IBA, ISO]
- positive regulation of JUN kinase activity [IMP]
- positive regulation of MAP kinase activity [IMP]
- positive regulation of NF-kappaB transcription factor activity [IDA, ISO]
- positive regulation of smooth muscle cell proliferation [ISO]
- protein autophosphorylation [IDA, ISO]
- protein oligomerization [ISO]
- protein phosphorylation [IBA, ISO]
- regulation of cytokine-mediated signaling pathway [ISO]
- response to interleukin-1 [ISO]
- response to lipopolysaccharide [IDA, ISO]
- response to peptidoglycan [IDA]
- toll-like receptor 2 signaling pathway [IDA, ISO]
- toll-like receptor 4 signaling pathway [IDA]
Gene Ontology Molecular Function
Affinity Capture-Western
An interaction is inferred when a bait protein is affinity captured from cell extracts by either polyclonal antibody or epitope tag and the associated interaction partner identified by Western blot with a specific polyclonal antibody or second epitope tag. This category is also used if an interacting protein is visualized directly by dye stain or radioactivity. Note that this differs from any co-purification experiment involving affinity capture in that the co-purification experiment involves at least one extra purification step to get rid of potential contaminating proteins.
Publication
Transient membrane recruitment of IRAK-1 in response to LPS and IL-1beta requires TNF R1.
The transcription factor NF-kappaB is an essential regulator of the innate immune response that functions as the first line of defense against infections. Activation of the innate immune response by bacterial lipopolysaccharide (LPS) triggers production of tumor necrosis factor-alpha (TNF-alpha) followed by interleukin-1 (IL-1). The IL-1 receptor associated kinase-1 (IRAK-1) is an integral component of the LPS, TNF-alpha, and IL-1 ... [more]
Throughput
- Low Throughput
Curated By
- BioGRID