BAIT

RAD26

DNA-dependent ATPase RAD26, L000001569, YJR035W
Protein involved in transcription-coupled nucleotide excision repair; repairs UV-induced DNA lesions; recruitment to DNA lesions is dependent on an elongating RNA polymerase II; homolog of human CSB protein
GO Process (3)
GO Function (1)
GO Component (2)

Gene Ontology Biological Process

Gene Ontology Molecular Function

Gene Ontology Cellular Component

Saccharomyces cerevisiae (S288c)
PREY

ELC1

elongin C, L000004351, YPL046C
Elongin C, conserved among eukaryotes; forms a complex with Cul3p that polyubiquitylates monoubiquitylated RNA polymerase II to trigger its proteolysis; plays a role in global genomic repair
UPS Project
Saccharomyces cerevisiae (S288c)

Phenotypic Enhancement

A genetic interaction is inferred when mutation or overexpression of one gene results in enhancement of any phenotype (other than lethality/growth defect) associated with mutation or over expression of another gene.

Publication

Yeast Elc1 plays an important role in global genomic repair but not in transcription coupled repair.

Lejeune D, Chen X, Ruggiero C, Berryhill S, Ding B, Li S

Transcription coupled repair (TCR) is a nucleotide excision repair (NER) pathway that is dedicated to repair in the transcribed strand of an active gene. The genome overall NER is called global genomic repair (GGR). Elc1, the yeast homolog of the mammalian elongation factor elongin C, has been shown to be a component of a ubiquitin ligase complex that contains Rad7 ... [more]

DNA Repair (Amst.) Jan. 01, 2009; 8(1);40-50 [Pubmed: 18817898]

Throughput

  • Low Throughput

Ontology Terms

  • uv resistance (APO:0000085)
  • mutation frequency (APO:0000198)

Additional Notes

  • Deletion of ELC1 in a rad26 single mutant or rad26 rpb9 double mutant further increases UV sensitivity of these mutants. The rad26 rpb9 elc1 triple mutant is more sensitive to UV irradiation because it is completely deficient in transcription coupled repair (TCR).

Related interactions

InteractionExperimental Evidence CodeDatasetThroughputScoreCurated ByNotes
RAD26 ELC1
Phenotypic Enhancement
Phenotypic Enhancement

A genetic interaction is inferred when mutation or overexpression of one gene results in enhancement of any phenotype (other than lethality/growth defect) associated with mutation or over expression of another gene.

Low-BioGRID
239007
ELC1 RAD26
Synthetic Growth Defect
Synthetic Growth Defect

A genetic interaction is inferred when mutations in separate genes, each of which alone causes a minimal phenotype, result in a significant growth defect under a given condition when combined in the same cell.

Low-BioGRID
429430

Curated By

  • BioGRID