PLA2G6
Gene Ontology Biological Process
- Fc-gamma receptor signaling pathway involved in phagocytosis [TAS]
- cardiolipin acyl-chain remodeling [TAS]
- cardiolipin biosynthetic process [IMP]
- glycerophospholipid biosynthetic process [TAS]
- innate immune response [TAS]
- phosphatidylcholine acyl-chain remodeling [TAS]
- phosphatidylethanolamine acyl-chain remodeling [TAS]
- phospholipid metabolic process [TAS]
- small molecule metabolic process [TAS]
Gene Ontology Molecular Function
HIF1AN
Gene Ontology Biological Process
- cellular response to hypoxia [TAS]
- negative regulation of Notch signaling pathway [IDA]
- negative regulation of transcription from RNA polymerase II promoter in response to hypoxia [IDA]
- oxidation-reduction process [IDA]
- peptidyl-asparagine hydroxylation [IDA, IMP]
- peptidyl-aspartic acid hydroxylation [IDA]
- peptidyl-histidine hydroxylation [IDA]
- positive regulation of myoblast differentiation [IDA]
- positive regulation of vasculogenesis [NAS]
- regulation of transcription from RNA polymerase II promoter in response to hypoxia [TAS]
Gene Ontology Molecular Function- NF-kappaB binding [IPI]
- Notch binding [IPI]
- ankyrin repeat binding [IPI]
- carboxylic acid binding [IDA]
- cofactor binding [IDA]
- iron ion binding [IDA]
- oxidoreductase activity, acting on paired donors, with incorporation or reduction of molecular oxygen, 2-oxoglutarate as one donor, and incorporation of one atom each of oxygen into both donors [EXP]
- oxygen sensor activity [NAS]
- peptidyl-asparagine 3-dioxygenase activity [IDA, IMP]
- peptidyl-histidine dioxygenase activity [IDA]
- protein binding [IPI]
- protein homodimerization activity [IDA]
- zinc ion binding [IDA]
- NF-kappaB binding [IPI]
- Notch binding [IPI]
- ankyrin repeat binding [IPI]
- carboxylic acid binding [IDA]
- cofactor binding [IDA]
- iron ion binding [IDA]
- oxidoreductase activity, acting on paired donors, with incorporation or reduction of molecular oxygen, 2-oxoglutarate as one donor, and incorporation of one atom each of oxygen into both donors [EXP]
- oxygen sensor activity [NAS]
- peptidyl-asparagine 3-dioxygenase activity [IDA, IMP]
- peptidyl-histidine dioxygenase activity [IDA]
- protein binding [IPI]
- protein homodimerization activity [IDA]
- zinc ion binding [IDA]
Gene Ontology Cellular Component
Affinity Capture-MS
An interaction is inferred when a bait protein is affinity captured from cell extracts by either polyclonal antibody or epitope tag and the associated interaction partner is identified by mass spectrometric methods.
Publication
The BioPlex Network of Human Protein Interactions: Additional Unpublished AP-MS Results (Pre-Publication)
As part of an ongoing effort led by Steve Gygi, Wade Harper, and Ed Huttlin in the Department of Cell Biology at Harvard Medical School, we are systematically profiling the interactions among human proteins using affinity purification mass spectrometry. In this effort, HA-tagged bait proteins obtained from the human ORFeome collection (version 8.1; Marc Vidal) are expressed individually in human ... [more]
Quantitative Score
- 0.999791048 [compPASS Score]
Throughput
- High Throughput
Additional Notes
- BioPlex HCT (unpublished interaction)
- BioPlex HCT HCT116 cells CompPASS score = 0.999791048083036, threshold = 0.362. Quantitative scores are calculated by CompPASS-Plus (Huttlin et al. Cell 2015, PMID: 26186194). The 0.362 threshold represents the top 2% of scores in HCT116.
Related interactions
| Interaction | Experimental Evidence Code | Dataset | Throughput | Score | Curated By | Notes |
|---|---|---|---|---|---|---|
| PLA2G6 HIF1AN | Affinity Capture-MS Affinity Capture-MS An interaction is inferred when a bait protein is affinity captured from cell extracts by either polyclonal antibody or epitope tag and the associated interaction partner is identified by mass spectrometric methods. | High | 0.9927 | BioGRID | 3042918 | |
| HIF1AN PLA2G6 | Affinity Capture-MS Affinity Capture-MS An interaction is inferred when a bait protein is affinity captured from cell extracts by either polyclonal antibody or epitope tag and the associated interaction partner is identified by mass spectrometric methods. | High | - | BioGRID | 2463583 |
Curated By
- BioGRID