USP48
Gene Ontology Biological Process
Gene Ontology Molecular Function
Gene Ontology Cellular Component
DRD3
Gene Ontology Biological Process
- G-protein coupled receptor internalization [IDA]
- G-protein coupled receptor signaling pathway [IDA]
- acid secretion [ISS]
- adenylate cyclase-activating dopamine receptor signaling pathway [IDA]
- adenylate cyclase-inhibiting dopamine receptor signaling pathway [IDA]
- arachidonic acid secretion [IDA]
- behavioral response to cocaine [IEP, ISS]
- cellular calcium ion homeostasis [IDA]
- circadian regulation of gene expression [ISS]
- dopamine metabolic process [IC]
- learning [NAS]
- learning or memory [NAS]
- locomotory behavior [ISS]
- musculoskeletal movement, spinal reflex action [ISS]
- negative regulation of adenylate cyclase activity [IDA]
- negative regulation of blood pressure [ISS]
- negative regulation of oligodendrocyte differentiation [ISS]
- negative regulation of protein kinase B signaling [ISS]
- negative regulation of protein secretion [IDA]
- positive regulation of cytokinesis [IMP]
- positive regulation of dopamine receptor signaling pathway [ISS]
- positive regulation of mitosis [ISS]
- prepulse inhibition [IMP]
- regulation of cAMP metabolic process [IDA]
- regulation of dopamine secretion [ISS]
- regulation of dopamine uptake involved in synaptic transmission [IC]
- response to cocaine [IEP]
- response to drug [ISS]
- response to ethanol [ISS]
- response to histamine [IDA]
- response to morphine [ISS]
- social behavior [NAS]
- visual learning [ISS]
Gene Ontology Molecular Function
Gene Ontology Cellular Component
Affinity Capture-MS
An interaction is inferred when a bait protein is affinity captured from cell extracts by either polyclonal antibody or epitope tag and the associated interaction partner is identified by mass spectrometric methods.
Publication
USP48 Is Upregulated by Mettl14 to Attenuate Hepatocellular Carcinoma via Regulating SIRT6 Stabilization.
Exploiting cancer metabolism for the clinical benefit of patients with hepatocellular carcinoma (HCC) is a topic under active investigation. Ubiquitin-specific peptidase 48 (USP48), a member of the ubiquitin-specific protease family, is involved in tumor growth, inflammation, and genome stability. However, the role of USP48 in HCC tumorigenesis remains unknown. In this study, we report that expression of USP48 is downregulated ... [more]
Throughput
- Low Throughput
Related interactions
| Interaction | Experimental Evidence Code | Dataset | Throughput | Score | Curated By | Notes |
|---|---|---|---|---|---|---|
| DRD3 USP48 | Affinity Capture-Western Affinity Capture-Western An interaction is inferred when a bait protein is affinity captured from cell extracts by either polyclonal antibody or epitope tag and the associated interaction partner identified by Western blot with a specific polyclonal antibody or second epitope tag. This category is also used if an interacting protein is visualized directly by dye stain or radioactivity. Note that this differs from any co-purification experiment involving affinity capture in that the co-purification experiment involves at least one extra purification step to get rid of potential contaminating proteins. | Low | - | BioGRID | - | |
| DRD3 USP48 | Two-hybrid Two-hybrid Bait protein expressed as a DNA binding domain (DBD) fusion and prey expressed as a transcriptional activation domain (TAD) fusion and interaction measured by reporter gene activation. | Low | - | BioGRID | - |
Curated By
- BioGRID