NCOR1
Gene Ontology Biological Process
- CD4-positive, CD25-positive, alpha-beta regulatory T cell differentiation [IMP]
- cholesterol homeostasis [IMP]
- circadian regulation of gene expression [IGI]
- definitive erythrocyte differentiation [IMP]
- negative regulation of JNK cascade [ISO]
- negative regulation of gene expression [ISO]
- negative regulation of phosphatidylinositol 3-kinase signaling [IMP]
- negative regulation of transcription from RNA polymerase II promoter [IGI, IMP, ISO]
- negative regulation of transcription, DNA-templated [IDA, IMP, ISO]
- positive regulation of cell proliferation [ISO]
- positive regulation of histone deacetylation [IDA]
- regulation of catalytic activity [IMP]
- regulation of glycolytic process by negative regulation of transcription from RNA polymerase II promoter [ISO]
- regulation of histone deacetylation [IMP]
- regulation of lipid transport by negative regulation of transcription from RNA polymerase II promoter [ISO]
- regulation of multicellular organism growth [IGI]
- regulation of transcription from RNA polymerase II promoter [IGI]
- spindle assembly [ISO]
- thalamus development [IMP]
Gene Ontology Molecular Function- DNA binding [IDA]
- RNA polymerase II activating transcription factor binding [ISO]
- RNA polymerase II regulatory region DNA binding [ISO]
- chromatin binding [ISO]
- estrogen receptor binding [ISO]
- histone deacetylase binding [ISO]
- histone deacetylase regulator activity [IDA, IMP]
- nuclear hormone receptor binding [ISO]
- peroxisome proliferator activated receptor binding [ISO]
- protein binding [IPI]
- protein domain specific binding [IPI, ISO]
- retinoic acid receptor binding [IDA, ISO]
- retinoid X receptor binding [IDA, ISO]
- sequence-specific DNA binding [IDA]
- sequence-specific DNA binding transcription factor activity [IDA]
- thyroid hormone receptor binding [IDA, IPI]
- transcription corepressor activity [IGI, ISO]
- transcription regulatory region DNA binding [IDA]
- DNA binding [IDA]
- RNA polymerase II activating transcription factor binding [ISO]
- RNA polymerase II regulatory region DNA binding [ISO]
- chromatin binding [ISO]
- estrogen receptor binding [ISO]
- histone deacetylase binding [ISO]
- histone deacetylase regulator activity [IDA, IMP]
- nuclear hormone receptor binding [ISO]
- peroxisome proliferator activated receptor binding [ISO]
- protein binding [IPI]
- protein domain specific binding [IPI, ISO]
- retinoic acid receptor binding [IDA, ISO]
- retinoid X receptor binding [IDA, ISO]
- sequence-specific DNA binding [IDA]
- sequence-specific DNA binding transcription factor activity [IDA]
- thyroid hormone receptor binding [IDA, IPI]
- transcription corepressor activity [IGI, ISO]
- transcription regulatory region DNA binding [IDA]
Gene Ontology Cellular Component
DZIP3
Gene Ontology Biological Process
Gene Ontology Molecular Function
Affinity Capture-Western
An interaction is inferred when a bait protein is affinity captured from cell extracts by either polyclonal antibody or epitope tag and the associated interaction partner identified by Western blot with a specific polyclonal antibody or second epitope tag. This category is also used if an interacting protein is visualized directly by dye stain or radioactivity. Note that this differs from any co-purification experiment involving affinity capture in that the co-purification experiment involves at least one extra purification step to get rid of potential contaminating proteins.
Publication
Histone H2A monoubiquitination represses transcription by inhibiting RNA polymerase II transcriptional elongation.
Solving the biological roles of covalent histone modifications, including monoubiquitination of histone H2A, and the molecular mechanisms by which these modifications regulate specific transcriptional programs remains a central question for all eukaryotes. Here we report that the N-CoR/HDAC1/3 complex specifically recruits a specific histone H2A ubiquitin ligase, 2A-HUB/hRUL138, to a subset of regulated gene promoters. 2A-HUB catalyzes monoubiquitination of H2A ... [more]
Throughput
- Low Throughput
Related interactions
| Interaction | Experimental Evidence Code | Dataset | Throughput | Score | Curated By | Notes |
|---|---|---|---|---|---|---|
| NCOR1 DZIP3 | Co-fractionation Co-fractionation Interaction inferred from the presence of two or more protein subunits in a partially purified protein preparation. If co-fractionation is demonstrated between 3 or more proteins, then add them as a complex. | Low | - | BioGRID | - |
Curated By
- BioGRID