BAIT
REV3L
POLZ, REV3, RP5-1112D6.1
REV3-like, polymerase (DNA directed), zeta, catalytic subunit
GO Process (3)
GO Function (3)
GO Component (3)
Gene Ontology Biological Process
Gene Ontology Molecular Function
Gene Ontology Cellular Component
Homo sapiens
PREY
MAD2L1
HSMAD2, MAD2
MAD2 mitotic arrest deficient-like 1 (yeast)
GO Process (11)
GO Function (3)
GO Component (6)
Gene Ontology Biological Process
- anaphase-promoting complex-dependent proteasomal ubiquitin-dependent protein catabolic process [TAS]
- mitotic cell cycle [TAS]
- mitotic cell cycle checkpoint [IDA, IGI]
- mitotic spindle assembly checkpoint [TAS]
- negative regulation of apoptotic process [IMP]
- negative regulation of mitotic anaphase-promoting complex activity [IDA]
- negative regulation of mitotic cell cycle [IMP]
- negative regulation of protein catabolic process [IDA]
- negative regulation of ubiquitin-protein ligase activity involved in mitotic cell cycle [TAS]
- positive regulation of mitotic cell cycle spindle assembly checkpoint [IMP]
- regulation of ubiquitin-protein ligase activity involved in mitotic cell cycle [TAS]
Gene Ontology Molecular Function
Gene Ontology Cellular Component
Homo sapiens
Reconstituted Complex
An interaction is detected between purified proteins in vitro.
Publication
Overlapping in short motif sequences for binding to human REV7 and MAD2 proteins.
Pol?, a DNA polymerase specialized for translesion DNA synthesis (TLS), is comprised of two subunits, the REV3 catalytic subunit and the REV7 accessory subunit. The human REV7 (hREV7) protein is known to interact with hREV3, hREV1 (another TLS protein) and some other proteins such as ADAM9 (a disintegrin and metalloprotease) and ELK-1 (an Ets-like transcription factor). hREV7 is alternatively termed ... [more]
Genes Cells Mar. 01, 2010; 15(3);281-96 [Pubmed: 20088965]
Throughput
- Low Throughput
Related interactions
| Interaction | Experimental Evidence Code | Dataset | Throughput | Score | Curated By | Notes |
|---|---|---|---|---|---|---|
| MAD2L1 REV3L | Reconstituted Complex Reconstituted Complex An interaction is detected between purified proteins in vitro. | Low | - | BioGRID | - | |
| REV3L MAD2L1 | Two-hybrid Two-hybrid Bait protein expressed as a DNA binding domain (DBD) fusion and prey expressed as a transcriptional activation domain (TAD) fusion and interaction measured by reporter gene activation. | Low | - | BioGRID | - |
Curated By
- BioGRID