BAIT
PDE4B
DPDE4, PDEIVB, RP5-876C12.1
phosphodiesterase 4B, cAMP-specific
GO Process (13)
GO Function (4)
GO Component (3)
Gene Ontology Biological Process
- T cell receptor signaling pathway [IMP]
- cAMP catabolic process [IDA, IGI]
- cellular response to drug [ISS]
- cellular response to epinephrine stimulus [ISS]
- cellular response to lipopolysaccharide [ISS]
- leukocyte migration [ISS]
- negative regulation of relaxation of cardiac muscle [ISS]
- neutrophil chemotaxis [ISS]
- neutrophil homeostasis [ISS]
- positive regulation of interferon-gamma production [IMP]
- positive regulation of interleukin-2 production [IMP]
- regulation of cardiac muscle cell contraction [ISS]
- regulation of high voltage-gated calcium channel activity [ISS]
Gene Ontology Molecular Function
Homo sapiens
PREY
MSH2
COCA1, FCC1, HNPCC, HNPCC1, LCFS2
mutS homolog 2
GO Process (22)
GO Function (25)
GO Component (4)
Gene Ontology Biological Process
- ATP catabolic process [IBA, IDA]
- B cell differentiation [ISS]
- B cell mediated immunity [ISS]
- DNA repair [IDA]
- double-strand break repair [IBA]
- intra-S DNA damage checkpoint [IBA]
- intrinsic apoptotic signaling pathway in response to DNA damage by p53 class mediator [IBA]
- isotype switching [IBA, ISS]
- maintenance of DNA repeat elements [IMP]
- male gonad development [ISS]
- meiotic gene conversion [IBA]
- meiotic mismatch repair [IBA]
- mismatch repair [IDA, IGI]
- negative regulation of DNA recombination [IDA, ISS]
- negative regulation of neuron apoptotic process [ISS]
- negative regulation of reciprocal meiotic recombination [IBA]
- positive regulation of helicase activity [IDA]
- postreplication repair [IDA]
- response to UV-B [IBA, ISS]
- response to X-ray [IBA, ISS]
- somatic hypermutation of immunoglobulin genes [IBA]
- somatic recombination of immunoglobulin gene segments [ISS]
Gene Ontology Molecular Function- ADP binding [IDA]
- ATP binding [IDA]
- ATPase activity [IDA]
- DNA binding [IDA]
- DNA-dependent ATPase activity [IBA]
- MutLalpha complex binding [IDA]
- Y-form DNA binding [IBA]
- dinucleotide insertion or deletion binding [IDA]
- dinucleotide repeat insertion binding [IDA]
- double-strand/single-strand DNA junction binding [IBA]
- double-stranded DNA binding [IDA]
- enzyme binding [IPI]
- four-way junction DNA binding [IDA]
- guanine/thymine mispair binding [IDA, IMP]
- heteroduplex DNA loop binding [IBA]
- magnesium ion binding [IDA]
- mismatched DNA binding [IDA]
- oxidized purine DNA binding [IDA]
- protein C-terminus binding [IPI]
- protein binding [IPI]
- protein homodimerization activity [IDA]
- protein kinase binding [IPI]
- single guanine insertion binding [IDA]
- single thymine insertion binding [IDA]
- single-stranded DNA binding [IDA]
- ADP binding [IDA]
- ATP binding [IDA]
- ATPase activity [IDA]
- DNA binding [IDA]
- DNA-dependent ATPase activity [IBA]
- MutLalpha complex binding [IDA]
- Y-form DNA binding [IBA]
- dinucleotide insertion or deletion binding [IDA]
- dinucleotide repeat insertion binding [IDA]
- double-strand/single-strand DNA junction binding [IBA]
- double-stranded DNA binding [IDA]
- enzyme binding [IPI]
- four-way junction DNA binding [IDA]
- guanine/thymine mispair binding [IDA, IMP]
- heteroduplex DNA loop binding [IBA]
- magnesium ion binding [IDA]
- mismatched DNA binding [IDA]
- oxidized purine DNA binding [IDA]
- protein C-terminus binding [IPI]
- protein binding [IPI]
- protein homodimerization activity [IDA]
- protein kinase binding [IPI]
- single guanine insertion binding [IDA]
- single thymine insertion binding [IDA]
- single-stranded DNA binding [IDA]
Gene Ontology Cellular Component
Homo sapiens
Protein-RNA
An interaction is detected between and protein and an RNA in vitro.
Publication
circPDE4B prevents articular cartilage degeneration and promotes repair by acting as a scaffold for RIC8A and MID1.
Circular RNAs (circRNAs) have emerged as significant biological regulators. Herein, we aimed to elucidate the role of an unidentified circRNA (circPDE4B) that is reportedly downregulated in osteoarthritis (OA) tissues.The effects of circPDE4B were explored in human and mouse chondrocytes in vitro. Specifically, RNA pull-down (RPD)-mass spectrometry analysis (MS), immunoprecipitation, glutathione-S-transferase (GST) pull-down, RNA immunoprecipitation and RPD assays were performed to ... [more]
Ann Rheum Dis Dec. 01, 2020; 80(9);1209-1219 [Pubmed: 34039624]
Throughput
- High Throughput
Additional Notes
- Bait is circPDE4B
Curated By
- BioGRID