BAIT
PDE4B
DPDE4, PDEIVB, RP5-876C12.1
phosphodiesterase 4B, cAMP-specific
GO Process (13)
GO Function (4)
GO Component (3)
Gene Ontology Biological Process
- T cell receptor signaling pathway [IMP]
- cAMP catabolic process [IDA, IGI]
- cellular response to drug [ISS]
- cellular response to epinephrine stimulus [ISS]
- cellular response to lipopolysaccharide [ISS]
- leukocyte migration [ISS]
- negative regulation of relaxation of cardiac muscle [ISS]
- neutrophil chemotaxis [ISS]
- neutrophil homeostasis [ISS]
- positive regulation of interferon-gamma production [IMP]
- positive regulation of interleukin-2 production [IMP]
- regulation of cardiac muscle cell contraction [ISS]
- regulation of high voltage-gated calcium channel activity [ISS]
Gene Ontology Molecular Function
Homo sapiens
PREY
CAPZA2
CAPPA2, CAPZ
capping protein (actin filament) muscle Z-line, alpha 2
GO Process (4)
GO Function (0)
GO Component (4)
Gene Ontology Biological Process
Gene Ontology Cellular Component
Homo sapiens
Protein-RNA
An interaction is detected between and protein and an RNA in vitro.
Publication
circPDE4B prevents articular cartilage degeneration and promotes repair by acting as a scaffold for RIC8A and MID1.
Circular RNAs (circRNAs) have emerged as significant biological regulators. Herein, we aimed to elucidate the role of an unidentified circRNA (circPDE4B) that is reportedly downregulated in osteoarthritis (OA) tissues.The effects of circPDE4B were explored in human and mouse chondrocytes in vitro. Specifically, RNA pull-down (RPD)-mass spectrometry analysis (MS), immunoprecipitation, glutathione-S-transferase (GST) pull-down, RNA immunoprecipitation and RPD assays were performed to ... [more]
Ann Rheum Dis Dec. 01, 2020; 80(9);1209-1219 [Pubmed: 34039624]
Throughput
- High Throughput
Additional Notes
- Bait is circPDE4B
Curated By
- BioGRID