RRAGA
Gene Ontology Biological Process
- GTP catabolic process [IBA]
- cell death [IDA]
- cellular protein localization [IMP]
- cellular response to amino acid stimulus [IMP]
- cellular response to starvation [IBA]
- modulation by virus of host morphology or physiology [IDA]
- positive regulation of TOR signaling [IBA, NAS]
- positive regulation of cytolysis [IDA]
- regulation of autophagy [IBA]
Gene Ontology Molecular Function
Gene Ontology Cellular Component
FNIP1
Gene Ontology Biological Process
- TOR signaling [IMP]
- cellular response to starvation [ISS]
- immature B cell differentiation [ISS]
- negative regulation of TOR signaling [ISS]
- negative regulation of cysteine-type endopeptidase activity involved in apoptotic process [ISS]
- negative regulation of transcription from RNA polymerase II promoter [IDA]
- positive regulation of B cell apoptotic process [ISS]
- positive regulation of GTPase activity [IDA]
- positive regulation of peptidyl-serine phosphorylation [IDA]
- positive regulation of protein phosphorylation [IMP]
- regulation of pro-B cell differentiation [ISS]
- regulation of protein phosphorylation [IDA]
Gene Ontology Molecular Function
Affinity Capture-Western
An interaction is inferred when a bait protein is affinity captured from cell extracts by either polyclonal antibody or epitope tag and the associated interaction partner identified by Western blot with a specific polyclonal antibody or second epitope tag. This category is also used if an interacting protein is visualized directly by dye stain or radioactivity. Note that this differs from any co-purification experiment involving affinity capture in that the co-purification experiment involves at least one extra purification step to get rid of potential contaminating proteins.
Publication
Recruitment of folliculin to lysosomes supports the amino acid-dependent activation of Rag GTPases.
Birt-Hogg-Dube syndrome, a human disease characterized by fibrofolliculomas (hair follicle tumors) as well as a strong predisposition toward the development of pneumothorax, pulmonary cysts, and renal carcinoma, arises from loss-of-function mutations in the folliculin (FLCN) gene. In this study, we show that FLCN regulates lysosome function by promoting the mTORC1-dependent phosphorylation and cytoplasmic sequestration of transcription factor EB (TFEB). Our ... [more]
Throughput
- Low Throughput
Curated By
- BioGRID