An interaction is inferred when a bait protein is affinity captured from cell extracts by either polyclonal antibody or epitope tag and the associated interaction partner is identified by mass spectrometric methods.

Publication

Reciprocal interaction between SIRT6 and APC/C regulates genomic stability.

Wang H, Feng K, Wang Q, Deng H

SIRT6 is an NAD+-dependent deacetylase that plays an important role in mitosis fidelity and genome stability. In the present study, we found that SIRT6 overexpression leads to mitosis defects and aneuploidy. We identified SIRT6 as a novel substrate of anaphase-promoting complex/cyclosome (APC/C), which is a master regulator of mitosis. Both CDH1 and CDC20, co-activators of APC/C, mediated SIRT6 degradation via ... [more]

Sci Rep Dec. 09, 2020; 11(1);14253 [Pubmed: 34244565]

Throughput

Low Throughput

Curated By

BioGRID

Interaction Summary

SIRT6

Gene Ontology Biological Process

Gene Ontology Molecular Function

NAD(P)+-protein-arginine ADP-ribosyltransferase activity [ISS]NAD+ ADP-ribosyltransferase activity [TAS]NAD+ binding [ISS]NAD-dependent histone deacetylase activity [ISS]NAD-dependent histone deacetylase activity (H3-K9 specific) [IDA]protein binding [IPI]zinc ion binding [ISS]

Gene Ontology Cellular Component

GIT1