BAIT
HIF1A
HIF-1A, HIF-1alpha, HIF1, HIF1-ALPHA, MOP1, PASD8, bHLHe78
hypoxia inducible factor 1, alpha subunit (basic helix-loop-helix transcription factor)
GO Process (34)
GO Function (13)
GO Component (7)
Gene Ontology Biological Process
- Notch signaling pathway [TAS]
- axon transport of mitochondrion [IMP]
- cellular response to hypoxia [IDA, IEP, TAS]
- cellular response to interleukin-1 [IEP]
- collagen metabolic process [ISS]
- connective tissue replacement involved in inflammatory response wound healing [ISS]
- elastin metabolic process [ISS]
- epithelial to mesenchymal transition [ISS]
- mRNA transcription from RNA polymerase II promoter [IC]
- negative regulation of oxidative stress-induced neuron intrinsic apoptotic signaling pathway [IDA]
- oxygen homeostasis [IDA]
- positive regulation of angiogenesis [IC]
- positive regulation of chemokine production [TAS]
- positive regulation of chemokine-mediated signaling pathway [IC]
- positive regulation of endothelial cell proliferation [IC]
- positive regulation of epithelial cell migration [ISS]
- positive regulation of erythrocyte differentiation [IC]
- positive regulation of glycolytic process [IC]
- positive regulation of hormone biosynthetic process [IDA]
- positive regulation of nitric-oxide synthase activity [TAS]
- positive regulation of receptor biosynthetic process [IMP]
- positive regulation of transcription from RNA polymerase II promoter [IDA, IGI]
- positive regulation of transcription from RNA polymerase II promoter in response to hypoxia [IDA, IMP]
- positive regulation of transcription, DNA-templated [IDA, IMP]
- positive regulation of vascular endothelial growth factor receptor signaling pathway [IC]
- positive regulation vascular endothelial growth factor production [IDA, IMP]
- regulation of gene expression [IDA]
- regulation of transcription from RNA polymerase II promoter in response to hypoxia [TAS]
- regulation of transcription from RNA polymerase II promoter in response to oxidative stress [IDA]
- regulation of transcription, DNA-templated [IDA]
- regulation of transforming growth factor beta2 production [IMP]
- response to hypoxia [IDA, IMP]
- signal transduction [IMP]
- vascular endothelial growth factor production [IDA]
Gene Ontology Molecular Function- Hsp90 protein binding [IDA]
- RNA polymerase II distal enhancer sequence-specific DNA binding transcription factor activity [IDA]
- enzyme binding [IPI]
- histone acetyltransferase binding [IPI]
- nuclear hormone receptor binding [IPI]
- protein binding [IPI]
- protein heterodimerization activity [IPI, TAS]
- protein kinase binding [IPI]
- sequence-specific DNA binding [IDA]
- sequence-specific DNA binding transcription factor activity [IDA, TAS]
- transcription factor binding [IPI]
- transcription factor binding transcription factor activity [IDA]
- ubiquitin protein ligase binding [IPI]
- Hsp90 protein binding [IDA]
- RNA polymerase II distal enhancer sequence-specific DNA binding transcription factor activity [IDA]
- enzyme binding [IPI]
- histone acetyltransferase binding [IPI]
- nuclear hormone receptor binding [IPI]
- protein binding [IPI]
- protein heterodimerization activity [IPI, TAS]
- protein kinase binding [IPI]
- sequence-specific DNA binding [IDA]
- sequence-specific DNA binding transcription factor activity [IDA, TAS]
- transcription factor binding [IPI]
- transcription factor binding transcription factor activity [IDA]
- ubiquitin protein ligase binding [IPI]
Gene Ontology Cellular Component
Homo sapiens
PREY
VHL
Vhlh
von Hippel-Lindau tumor suppressor, E3 ubiquitin protein ligase
GO Process (20)
GO Function (6)
GO Component (13)
Gene Ontology Biological Process
- NLS-bearing protein import into nucleus [ISO]
- angiogenesis [ISO]
- blood vessel endothelial cell migration [ISO]
- extracellular matrix organization [ISO]
- negative regulation of thymocyte apoptotic process [ISO]
- negative regulation of transcription from RNA polymerase II promoter [IMP]
- negative regulation of transcription from RNA polymerase II promoter in response to hypoxia [ISO]
- neuron differentiation [IDA]
- positive regulation of transcription, DNA-templated [ISO]
- proteasomal protein catabolic process [ISO]
- protein catabolic process [ISO]
- protein heterooligomerization [IPI]
- protein transport [ISO]
- protein ubiquitination [ISO]
- regulation of apoptotic signaling pathway [ISO]
- regulation of catecholamine metabolic process [IMP]
- regulation of thymocyte apoptotic process [ISO]
- regulation of transcription, DNA-templated [IDA, ISO]
- response to ethanol [IEP]
- response to hypoxia [IMP]
Gene Ontology Molecular Function
Gene Ontology Cellular Component
Rattus norvegicus
Reconstituted Complex
An interaction is detected between purified proteins in vitro.
Publication
Hypoxia-inducible factor-1alpha stabilization in nonhypoxic conditions: role of oxidation and intracellular ascorbate depletion.
Hypoxia-inducible factor-1 (HIF-1) is a decisive element for the transcriptional regulation of many genes induced under low oxygen conditions. Under normal oxygen conditions, HIF-1alpha, the active subunit of HIF-1, is hydroxylated on proline residues by specific HIF prolyl-hydroxylases, leading to ubiquitination and degradation by the proteasome. In hypoxia, hydroxylation and ubiquitination are blocked and HIF-1alpha accumulates in cells. Recent studies ... [more]
Mol. Biol. Cell Jan. 01, 2008; 19(1);86-94 [Pubmed: 17942596]
Throughput
- Low Throughput
Additional Notes
- Hif1a not confirmed human
Curated By
- BioGRID