CAV1
Gene Ontology Biological Process
- T cell costimulation [IDA]
- apoptotic signaling pathway [IMP]
- blood coagulation [TAS]
- calcium ion homeostasis [ISS]
- calcium ion transport [ISS]
- caveola assembly [IGI, IMP]
- caveolin-mediated endocytosis [IDA]
- cellular calcium ion homeostasis [ISS]
- cellular response to hyperoxia [IMP]
- cellular response to starvation [IEP]
- cholesterol homeostasis [ISS, TAS]
- cholesterol transport [TAS]
- cytosolic calcium ion homeostasis [IDA]
- inactivation of MAPK activity [ISS]
- leukocyte migration [TAS]
- lipid storage [ISS]
- maintenance of protein location in cell [ISS]
- mammary gland development [ISS]
- mammary gland involution [ISS]
- membrane depolarization [ISS]
- negative regulation of BMP signaling pathway [IDA]
- negative regulation of JAK-STAT cascade [ISS]
- negative regulation of MAPK cascade [ISS]
- negative regulation of anoikis [IMP]
- negative regulation of canonical Wnt signaling pathway [ISS]
- negative regulation of endothelial cell proliferation [ISS]
- negative regulation of epithelial cell differentiation [ISS]
- negative regulation of nitric oxide biosynthetic process [ISS]
- negative regulation of peptidyl-serine phosphorylation [IDA]
- negative regulation of peptidyl-tyrosine autophosphorylation [IMP]
- negative regulation of pinocytosis [IMP]
- negative regulation of potassium ion transmembrane transport [IMP]
- negative regulation of protein binding [IDA]
- negative regulation of protein tyrosine kinase activity [IMP]
- negative regulation of protein ubiquitination [IMP]
- negative regulation of transcription from RNA polymerase II promoter [ISS]
- nitric oxide homeostasis [ISS]
- nitric oxide metabolic process [TAS]
- positive regulation of calcium ion transport into cytosol [ISS]
- positive regulation of canonical Wnt signaling pathway [IMP]
- positive regulation of extrinsic apoptotic signaling pathway [IMP]
- positive regulation of intrinsic apoptotic signaling pathway [IMP]
- positive regulation of metalloenzyme activity [ISS]
- positive regulation of peptidyl-serine phosphorylation [IDA]
- positive regulation of vasoconstriction [ISS]
- protein homooligomerization [ISS]
- protein localization [ISS]
- receptor internalization involved in canonical Wnt signaling pathway [IMP]
- regulation of blood coagulation [IMP]
- regulation of cardiac muscle cell action potential involved in regulation of contraction [IC]
- regulation of fatty acid metabolic process [ISS]
- regulation of inward rectifier potassium channel activity [IMP]
- regulation of membrane repolarization during action potential [IMP]
- regulation of nitric-oxide synthase activity [TAS]
- regulation of peptidase activity [ISS]
- regulation of smooth muscle contraction [ISS]
- response to calcium ion [ISS]
- response to estrogen [IDA]
- response to hypoxia [ISS]
- response to progesterone [IDA]
- skeletal muscle tissue development [ISS]
- small molecule metabolic process [TAS]
- triglyceride metabolic process [ISS]
- vasculogenesis [ISS]
- vesicle organization [IDA]
Gene Ontology Molecular Function- cholesterol binding [TAS]
- enzyme binding [IPI]
- identical protein binding [IPI]
- inward rectifier potassium channel inhibitor activity [IDA]
- ion channel binding [IPI]
- nitric-oxide synthase binding [IPI]
- patched binding [NAS]
- peptidase activator activity [ISS]
- protein binding [IPI]
- protein complex scaffold [TAS]
- protein kinase binding [IPI]
- receptor binding [IPI]
- structural molecule activity [IDA]
- cholesterol binding [TAS]
- enzyme binding [IPI]
- identical protein binding [IPI]
- inward rectifier potassium channel inhibitor activity [IDA]
- ion channel binding [IPI]
- nitric-oxide synthase binding [IPI]
- patched binding [NAS]
- peptidase activator activity [ISS]
- protein binding [IPI]
- protein complex scaffold [TAS]
- protein kinase binding [IPI]
- receptor binding [IPI]
- structural molecule activity [IDA]
Gene Ontology Cellular Component
- Golgi membrane [IDA, TAS]
- apical plasma membrane [IDA]
- basolateral plasma membrane [IDA]
- caveola [IDA, NAS]
- cytoplasmic vesicle [IDA]
- endocytic vesicle membrane [TAS]
- endoplasmic reticulum [IDA]
- endosome [IDA]
- focal adhesion [IDA]
- intracellular [IDA]
- lipid particle [TAS]
- membrane raft [IDA]
- perinuclear region of cytoplasm [IDA, ISS]
- plasma membrane [IDA, TAS]
- protein complex [IDA]
KCNA3
Gene Ontology Biological Process
Gene Ontology Molecular Function
Gene Ontology Cellular Component
Affinity Capture-Western
An interaction is inferred when a bait protein is affinity captured from cell extracts by either polyclonal antibody or epitope tag and the associated interaction partner identified by Western blot with a specific polyclonal antibody or second epitope tag. This category is also used if an interacting protein is visualized directly by dye stain or radioactivity. Note that this differs from any co-purification experiment involving affinity capture in that the co-purification experiment involves at least one extra purification step to get rid of potential contaminating proteins.
Publication
A novel mitochondrial Kv1.3-caveolin axis controls cell survival and apoptosis.
The voltage-gated potassium channel Kv1.3 plays an apparent dual physiological role by participating in activation and proliferation of leukocytes as well as promoting apoptosis in several types of tumor cells. Therefore, Kv1.3 is considered a potential pharmacological target for immunodeficiency and cancer. Different cellular locations of Kv1.3, at the plasma membrane or the mitochondria, could be responsible for such duality. ... [more]
Throughput
- Low Throughput
Related interactions
| Interaction | Experimental Evidence Code | Dataset | Throughput | Score | Curated By | Notes |
|---|---|---|---|---|---|---|
| CAV1 KCNA3 | Affinity Capture-Western Affinity Capture-Western An interaction is inferred when a bait protein is affinity captured from cell extracts by either polyclonal antibody or epitope tag and the associated interaction partner identified by Western blot with a specific polyclonal antibody or second epitope tag. This category is also used if an interacting protein is visualized directly by dye stain or radioactivity. Note that this differs from any co-purification experiment involving affinity capture in that the co-purification experiment involves at least one extra purification step to get rid of potential contaminating proteins. | Low | - | BioGRID | - | |
| CAV1 KCNA3 | Affinity Capture-Western Affinity Capture-Western An interaction is inferred when a bait protein is affinity captured from cell extracts by either polyclonal antibody or epitope tag and the associated interaction partner identified by Western blot with a specific polyclonal antibody or second epitope tag. This category is also used if an interacting protein is visualized directly by dye stain or radioactivity. Note that this differs from any co-purification experiment involving affinity capture in that the co-purification experiment involves at least one extra purification step to get rid of potential contaminating proteins. | Low | - | BioGRID | - | |
| KCNA3 CAV1 | Co-fractionation Co-fractionation Interaction inferred from the presence of two or more protein subunits in a partially purified protein preparation. If co-fractionation is demonstrated between 3 or more proteins, then add them as a complex. | Low | - | BioGRID | - | |
| CAV1 KCNA3 | FRET FRET An interaction is inferred when close proximity of interaction partners is detected by fluorescence resonance energy transfer between pairs of fluorophore-labeled molecules, such as occurs between CFP (donor) and YFP (acceptor) fusion proteins. | Low | - | BioGRID | - | |
| CAV1 KCNA3 | FRET FRET An interaction is inferred when close proximity of interaction partners is detected by fluorescence resonance energy transfer between pairs of fluorophore-labeled molecules, such as occurs between CFP (donor) and YFP (acceptor) fusion proteins. | Low | - | BioGRID | - |
Curated By
- BioGRID