BAIT

CCL1

I-309, P500, SCYA1, SISe, TCA3
chemokine (C-C motif) ligand 1
GO Process (5)
GO Function (0)
GO Component (0)

Gene Ontology Biological Process

Homo sapiens
PREY

GPR19

G protein-coupled receptor 19
GO Process (0)
GO Function (0)
GO Component (1)

Gene Ontology Cellular Component

Homo sapiens

Affinity Capture-MS

An interaction is inferred when a bait protein is affinity captured from cell extracts by either polyclonal antibody or epitope tag and the associated interaction partner is identified by mass spectrometric methods.

Publication

The chemokine CCL1 triggers an AMFR-SPRY1 pathway that promotes differentiation of lung fibroblasts into myofibroblasts and drives pulmonary fibrosis.

Liu SS, Liu C, Lv XX, Cui B, Yan J, Li YX, Li K, Hua F, Zhang XW, Yu JJ, Yu JM, Wang F, Shang S, Li PP, Zhou ZG, Xiao Y, Hu ZW

Recruitment of immune cells to the site of inflammation by the chemokine CCL1 is important in the pathology of inflammatory diseases. Here, we examined the role of CCL1 in pulmonary fibrosis (PF). Bronchoalveolar lavage fluid from PF mouse models contained high amounts of CCL1, as did lung biopsies from PF patients. Immunofluorescence analyses revealed that alveolar macrophages and CD4+ T cells ... [more]

Immunity Dec. 14, 2020; 54(9);2042-2056.e8 [Pubmed: 34407391]

Throughput

  • Low Throughput

Curated By

  • BioGRID