BAIT
RAC1
Rac-1, TC-25, p21-Rac1, MIG5
ras-related C3 botulinum toxin substrate 1 (rho family, small GTP binding protein Rac1)
GO Process (41)
GO Function (6)
GO Component (10)
Gene Ontology Biological Process
- Fc-epsilon receptor signaling pathway [TAS]
- Fc-gamma receptor signaling pathway involved in phagocytosis [TAS]
- GTP catabolic process [TAS]
- T cell costimulation [TAS]
- actin cytoskeleton organization [IGI]
- actin filament polymerization [TAS]
- anatomical structure morphogenesis [TAS]
- apoptotic signaling pathway [TAS]
- axon guidance [TAS]
- blood coagulation [TAS]
- cell adhesion [TAS]
- cell motility [IDA]
- cell-matrix adhesion [NAS]
- cellular component movement [TAS]
- inflammatory response [TAS]
- innate immune response [TAS]
- intracellular signal transduction [TAS]
- lamellipodium assembly [IMP]
- localization within membrane [IMP]
- negative regulation of interleukin-23 production [IDA]
- negative regulation of receptor-mediated endocytosis [TAS]
- neurotrophin TRK receptor signaling pathway [TAS]
- platelet activation [TAS]
- positive regulation of Rho protein signal transduction [TAS]
- positive regulation of apoptotic process [TAS]
- positive regulation of cell-substrate adhesion [IGI]
- positive regulation of focal adhesion assembly [IDA]
- positive regulation of lamellipodium assembly [IDA, IMP]
- positive regulation of neutrophil chemotaxis [IMP]
- positive regulation of protein phosphorylation [IMP]
- positive regulation of stress fiber assembly [IDA]
- positive regulation of substrate adhesion-dependent cell spreading [IDA]
- regulation of cell migration [IMP]
- regulation of defense response to virus by virus [TAS]
- regulation of hydrogen peroxide metabolic process [TAS]
- regulation of respiratory burst [IDA]
- response to wounding [TAS]
- ruffle organization [IDA, TAS]
- semaphorin-plexin signaling pathway [ISS]
- substrate adhesion-dependent cell spreading [IMP]
- viral process [TAS]
Gene Ontology Molecular Function
Gene Ontology Cellular Component
Homo sapiens
PREY
LRP5
BMND1, EVR1, EVR4, HBM, LR3, LRP-5, LRP7, OPPG, OPS, OPTA1, VBCH2
low density lipoprotein receptor-related protein 5
GO Process (29)
GO Function (5)
GO Component (2)
Gene Ontology Biological Process
- Wnt signaling pathway [IDA]
- Wnt signaling pathway involved in dorsal/ventral axis specification [IDA]
- adipose tissue development [IMP]
- anterior/posterior pattern specification [IBA]
- bone marrow development [IMP]
- bone morphogenesis [IMP]
- bone remodeling [IBA]
- branching involved in mammary gland duct morphogenesis [IBA]
- canonical Wnt signaling pathway [IDA, IMP]
- cholesterol homeostasis [IMP]
- embryonic camera-type eye morphogenesis [IBA]
- embryonic limb morphogenesis [IBA]
- embryonic retina morphogenesis in camera-type eye [IBA]
- gastrulation with mouth forming second [IBA]
- glucose catabolic process [IMP]
- negative regulation of osteoblast differentiation [IMP]
- negative regulation of protein serine/threonine kinase activity [IMP]
- osteoblast development [IBA]
- positive regulation of cell proliferation [IDA]
- positive regulation of fat cell differentiation [IMP]
- positive regulation of mesenchymal cell proliferation [IMP]
- positive regulation of mitosis [IDA]
- positive regulation of transcription from RNA polymerase II promoter [IDA]
- positive regulation of transcription, DNA-templated [IDA]
- regulation of blood pressure [IMP]
- regulation of canonical Wnt signaling pathway [IMP]
- regulation of insulin secretion involved in cellular response to glucose stimulus [IBA]
- retina morphogenesis in camera-type eye [IMP]
- retinal blood vessel morphogenesis [IMP]
Gene Ontology Molecular Function
Gene Ontology Cellular Component
Homo sapiens
Affinity Capture-MS
An interaction is inferred when a bait protein is affinity captured from cell extracts by either polyclonal antibody or epitope tag and the associated interaction partner is identified by mass spectrometric methods.
Publication
Mapping the proximity interaction network of the Rho-family GTPases reveals signalling pathways and regulatory mechanisms.
Guanine nucleotide exchange factors (RhoGEFs) and GTPase-activating proteins (RhoGAPs) coordinate the activation state of the Rho family of GTPases for binding to effectors. Here, we exploited proximity-dependent biotinylation to systematically define the Rho family proximity interaction network from 28 baits to produce 9,939 high-confidence proximity interactions in two cell lines. Exploiting the nucleotide states of Rho GTPases, we revealed the ... [more]
Nat. Cell Biol. Dec. 23, 2019; (); [Pubmed: 31871319]
Throughput
- Low Throughput
Additional Notes
- AvgP greater or equal to 0.95 assessed by SAINT express
- BioID
- RAC1-G12V active mutant bait, interaction in Hela cells
Curated By
- BioGRID