HTT
Gene Ontology Biological Process
- ER to Golgi vesicle-mediated transport [IMP]
- Golgi organization [ISO]
- L-glutamate import [IMP]
- anatomical structure morphogenesis [IMP]
- anterior/posterior pattern specification [IMP]
- apoptotic process [IMP]
- associative learning [IMP]
- axon cargo transport [IMP]
- brain development [IMP]
- cell aging [IMP]
- central nervous system development [IMP]
- citrulline metabolic process [IMP]
- determination of adult lifespan [IMP]
- dopamine receptor signaling pathway [IMP]
- embryo development [IMP]
- endoplasmic reticulum organization [IMP]
- endosomal transport [IMP]
- establishment of mitotic spindle orientation [ISO]
- gastrulation [IMP]
- grooming behavior [IMP]
- hormone metabolic process [IMP]
- insulin secretion [IMP]
- iron ion homeostasis [IMP]
- lactate biosynthetic process from pyruvate [IMP]
- learning [IMP]
- learning or memory [IMP]
- locomotory behavior [IMP]
- mRNA transport [ISO]
- mitochondrial transport [IMP]
- mitochondrion organization [IMP]
- negative regulation of apoptotic process [IDA]
- negative regulation of cysteine-type endopeptidase activity [ISO]
- negative regulation of extrinsic apoptotic signaling pathway [ISO]
- negative regulation of neuron apoptotic process [IMP]
- negative regulation of neuron death [IMP]
- neural plate formation [IMP]
- neurogenesis [IMP]
- neuron apoptotic process [IMP]
- neuron development [IMP]
- olfactory lobe development [IMP]
- paraxial mesoderm formation [IMP]
- peptide hormone secretion [IMP]
- positive regulation of inositol 1,4,5-trisphosphate-sensitive calcium-release channel activity [ISO]
- protein import into nucleus [IMP]
- quinolinate biosynthetic process [IMP]
- regulation of mitochondrial membrane permeability [IMP]
- regulation of mitochondrial membrane potential [IMP]
- regulation of protein phosphatase type 2A activity [ISO]
- regulation of synaptic plasticity [IMP]
- response to calcium ion [IMP]
- retrograde vesicle-mediated transport, Golgi to ER [ISO]
- social behavior [IMP]
- spermatogenesis [IMP]
- striatum development [IMP]
- urea cycle [IMP]
- vesicle transport along microtubule [IDA, ISO]
- visual learning [IMP]
Gene Ontology Molecular Function
Gene Ontology Cellular Component
- Golgi apparatus [ISO]
- autophagic vacuole [ISO]
- axon [IDA, ISO]
- cell [IMP]
- clathrin-coated vesicle [ISO]
- cytoplasm [IDA, IMP, ISO]
- cytoplasmic membrane-bounded vesicle [IDA]
- cytoplasmic vesicle membrane [ISO]
- cytosol [ISO]
- dendrite [ISO]
- endoplasmic reticulum [ISO]
- inclusion body [IDA]
- intracellular [IMP]
- late endosome [ISO]
- mitochondrion [IMP]
- neuronal cell body [ISO]
- neuronal ribonucleoprotein granule [ISO]
- nucleoplasm [ISO]
- nucleus [IBA, ISO]
- postsynaptic density [ISO]
- protein complex [ISO]
FOXP1
Gene Ontology Biological Process
- cardiac muscle cell differentiation [IMP]
- cardiovascular system development [IGI, IMP]
- embryo development [IGI, IMP]
- heart development [IMP]
- immunoglobulin V(D)J recombination [IMP]
- in utero embryonic development [IMP]
- lung development [IGI]
- lung secretory cell differentiation [IGI]
- motor neuron axon guidance [IMP]
- negative regulation of lung goblet cell differentiation [IGI]
- negative regulation of transcription from RNA polymerase II promoter [IDA, IGI]
- negative regulation of transcription, DNA-templated [IDA]
- positive regulation of cardiac muscle cell differentiation [IMP]
- positive regulation of epithelial cell proliferation [IGI]
- positive regulation of immunoglobulin production [IMP]
- positive regulation of mesenchymal cell proliferation [IGI]
- positive regulation of transcription from RNA polymerase II promoter [IMP]
- positive regulation of transcription, DNA-templated [IMP]
- pre-B cell differentiation [IMP]
- regulation of cardiac muscle cell proliferation [IGI, IMP]
- regulation of lung goblet cell differentiation [IGI]
- sarcomere organization [IGI]
- skeletal muscle tissue development [IGI]
- smooth muscle tissue development [IGI]
- transcription from RNA polymerase II promoter [IGI]
Gene Ontology Molecular Function- DNA binding [IDA]
- RNA polymerase II core promoter proximal region sequence-specific DNA binding [IMP]
- RNA polymerase II distal enhancer sequence-specific DNA binding transcription factor activity [IDA, IGI]
- chromatin binding [IDA]
- protein binding [IPI]
- protein heterodimerization activity [IPI]
- protein homodimerization activity [IPI]
- sequence-specific DNA binding transcription factor activity [IDA]
- DNA binding [IDA]
- RNA polymerase II core promoter proximal region sequence-specific DNA binding [IMP]
- RNA polymerase II distal enhancer sequence-specific DNA binding transcription factor activity [IDA, IGI]
- chromatin binding [IDA]
- protein binding [IPI]
- protein heterodimerization activity [IPI]
- protein homodimerization activity [IPI]
- sequence-specific DNA binding transcription factor activity [IDA]
Affinity Capture-MS
An interaction is inferred when a bait protein is affinity captured from cell extracts by either polyclonal antibody or epitope tag and the associated interaction partner is identified by mass spectrometric methods.
Publication
Network organization of the huntingtin proteomic interactome in mammalian brain.
We used affinity-purification mass spectrometry to identify 747 candidate proteins that are complexed with Huntingtin (Htt) in distinct brain regions and ages in Huntington's disease (HD) and wild-type mouse brains. To gain a systems-level view of the Htt interactome, we applied Weighted Correlation Network Analysis to the entire proteomic data set to unveil a verifiable rank of Htt-correlated proteins and ... [more]
Throughput
- High Throughput
Related interactions
| Interaction | Experimental Evidence Code | Dataset | Throughput | Score | Curated By | Notes |
|---|---|---|---|---|---|---|
| FOXP1 HTT | Affinity Capture-Western Affinity Capture-Western An interaction is inferred when a bait protein is affinity captured from cell extracts by either polyclonal antibody or epitope tag and the associated interaction partner identified by Western blot with a specific polyclonal antibody or second epitope tag. This category is also used if an interacting protein is visualized directly by dye stain or radioactivity. Note that this differs from any co-purification experiment involving affinity capture in that the co-purification experiment involves at least one extra purification step to get rid of potential contaminating proteins. | Low | - | BioGRID | 668862 |
Curated By
- BioGRID