BAIT
FOXP1
3110052D19Rik, 4932443N09Rik, AI461938, AW494214
forkhead box P1
GO Process (25)
GO Function (8)
GO Component (1)
Gene Ontology Biological Process
- cardiac muscle cell differentiation [IMP]
- cardiovascular system development [IGI, IMP]
- embryo development [IGI, IMP]
- heart development [IMP]
- immunoglobulin V(D)J recombination [IMP]
- in utero embryonic development [IMP]
- lung development [IGI]
- lung secretory cell differentiation [IGI]
- motor neuron axon guidance [IMP]
- negative regulation of lung goblet cell differentiation [IGI]
- negative regulation of transcription from RNA polymerase II promoter [IDA, IGI]
- negative regulation of transcription, DNA-templated [IDA]
- positive regulation of cardiac muscle cell differentiation [IMP]
- positive regulation of epithelial cell proliferation [IGI]
- positive regulation of immunoglobulin production [IMP]
- positive regulation of mesenchymal cell proliferation [IGI]
- positive regulation of transcription from RNA polymerase II promoter [IMP]
- positive regulation of transcription, DNA-templated [IMP]
- pre-B cell differentiation [IMP]
- regulation of cardiac muscle cell proliferation [IGI, IMP]
- regulation of lung goblet cell differentiation [IGI]
- sarcomere organization [IGI]
- skeletal muscle tissue development [IGI]
- smooth muscle tissue development [IGI]
- transcription from RNA polymerase II promoter [IGI]
Gene Ontology Molecular Function- DNA binding [IDA]
- RNA polymerase II core promoter proximal region sequence-specific DNA binding [IMP]
- RNA polymerase II distal enhancer sequence-specific DNA binding transcription factor activity [IDA, IGI]
- chromatin binding [IDA]
- protein binding [IPI]
- protein heterodimerization activity [IPI]
- protein homodimerization activity [IPI]
- sequence-specific DNA binding transcription factor activity [IDA]
- DNA binding [IDA]
- RNA polymerase II core promoter proximal region sequence-specific DNA binding [IMP]
- RNA polymerase II distal enhancer sequence-specific DNA binding transcription factor activity [IDA, IGI]
- chromatin binding [IDA]
- protein binding [IPI]
- protein heterodimerization activity [IPI]
- protein homodimerization activity [IPI]
- sequence-specific DNA binding transcription factor activity [IDA]
Mus musculus
PREY
HTT
AI256365, C430023I11Rik, Hd, Hdh, IT15
huntingtin
GO Process (57)
GO Function (10)
GO Component (21)
Gene Ontology Biological Process
- ER to Golgi vesicle-mediated transport [IMP]
- Golgi organization [ISO]
- L-glutamate import [IMP]
- anatomical structure morphogenesis [IMP]
- anterior/posterior pattern specification [IMP]
- apoptotic process [IMP]
- associative learning [IMP]
- axon cargo transport [IMP]
- brain development [IMP]
- cell aging [IMP]
- central nervous system development [IMP]
- citrulline metabolic process [IMP]
- determination of adult lifespan [IMP]
- dopamine receptor signaling pathway [IMP]
- embryo development [IMP]
- endoplasmic reticulum organization [IMP]
- endosomal transport [IMP]
- establishment of mitotic spindle orientation [ISO]
- gastrulation [IMP]
- grooming behavior [IMP]
- hormone metabolic process [IMP]
- insulin secretion [IMP]
- iron ion homeostasis [IMP]
- lactate biosynthetic process from pyruvate [IMP]
- learning [IMP]
- learning or memory [IMP]
- locomotory behavior [IMP]
- mRNA transport [ISO]
- mitochondrial transport [IMP]
- mitochondrion organization [IMP]
- negative regulation of apoptotic process [IDA]
- negative regulation of cysteine-type endopeptidase activity [ISO]
- negative regulation of extrinsic apoptotic signaling pathway [ISO]
- negative regulation of neuron apoptotic process [IMP]
- negative regulation of neuron death [IMP]
- neural plate formation [IMP]
- neurogenesis [IMP]
- neuron apoptotic process [IMP]
- neuron development [IMP]
- olfactory lobe development [IMP]
- paraxial mesoderm formation [IMP]
- peptide hormone secretion [IMP]
- positive regulation of inositol 1,4,5-trisphosphate-sensitive calcium-release channel activity [ISO]
- protein import into nucleus [IMP]
- quinolinate biosynthetic process [IMP]
- regulation of mitochondrial membrane permeability [IMP]
- regulation of mitochondrial membrane potential [IMP]
- regulation of protein phosphatase type 2A activity [ISO]
- regulation of synaptic plasticity [IMP]
- response to calcium ion [IMP]
- retrograde vesicle-mediated transport, Golgi to ER [ISO]
- social behavior [IMP]
- spermatogenesis [IMP]
- striatum development [IMP]
- urea cycle [IMP]
- vesicle transport along microtubule [IDA, ISO]
- visual learning [IMP]
Gene Ontology Molecular Function
Gene Ontology Cellular Component
- Golgi apparatus [ISO]
- autophagic vacuole [ISO]
- axon [IDA, ISO]
- cell [IMP]
- clathrin-coated vesicle [ISO]
- cytoplasm [IDA, IMP, ISO]
- cytoplasmic membrane-bounded vesicle [IDA]
- cytoplasmic vesicle membrane [ISO]
- cytosol [ISO]
- dendrite [ISO]
- endoplasmic reticulum [ISO]
- inclusion body [IDA]
- intracellular [IMP]
- late endosome [ISO]
- mitochondrion [IMP]
- neuronal cell body [ISO]
- neuronal ribonucleoprotein granule [ISO]
- nucleoplasm [ISO]
- nucleus [IBA, ISO]
- postsynaptic density [ISO]
- protein complex [ISO]
Mus musculus
Affinity Capture-Western
An interaction is inferred when a bait protein is affinity captured from cell extracts by either polyclonal antibody or epitope tag and the associated interaction partner identified by Western blot with a specific polyclonal antibody or second epitope tag. This category is also used if an interacting protein is visualized directly by dye stain or radioactivity. Note that this differs from any co-purification experiment involving affinity capture in that the co-purification experiment involves at least one extra purification step to get rid of potential contaminating proteins.
Publication
Forkhead box protein p1 is a transcriptional repressor of immune signaling in the CNS: implications for transcriptional dysregulation in Huntington disease.
Forkhead box protein p1 (Foxp1), a transcription factor showing highly enriched expression in the striatum, has been implicated in central nervous system (CNS) development, but its role in the mature brain is unknown. In order to ascertain functional roles for Foxp1 in the CNS, we have identified gene targets for Foxp1 both in vitro and in vivo using genome-wide expression ... [more]
Hum. Mol. Genet. Jul. 15, 2012; 21(14);3097-111 [Pubmed: 22492998]
Throughput
- Low Throughput
Additional Notes
- figure 6.
Related interactions
| Interaction | Experimental Evidence Code | Dataset | Throughput | Score | Curated By | Notes |
|---|---|---|---|---|---|---|
| HTT FOXP1 | Affinity Capture-MS Affinity Capture-MS An interaction is inferred when a bait protein is affinity captured from cell extracts by either polyclonal antibody or epitope tag and the associated interaction partner is identified by mass spectrometric methods. | High | - | BioGRID | - |
Curated By
- BioGRID