BAIT
SIRT2
SIR2, SIR2L, SIR2L2
sirtuin 2
GO Process (50)
GO Function (15)
GO Component (22)
Gene Ontology Biological Process
- cellular lipid catabolic process [ISS]
- cellular response to caloric restriction [ISS]
- cellular response to epinephrine stimulus [ISS]
- cellular response to hepatocyte growth factor stimulus [IDA]
- cellular response to hypoxia [IDA]
- cellular response to molecule of bacterial origin [IDA]
- cellular response to oxidative stress [ISS]
- chromatin silencing [NAS]
- chromatin silencing at rDNA [NAS]
- chromatin silencing at telomere [NAS]
- gene silencing [NAS]
- hepatocyte growth factor receptor signaling pathway [IDA]
- histone H3 deacetylation [IMP]
- histone H4 deacetylation [IDA]
- histone deacetylation [IDA, TAS]
- myelination in peripheral nervous system [ISS]
- negative regulation of autophagy [IMP]
- negative regulation of cell proliferation [IMP]
- negative regulation of defense response to bacterium [IMP]
- negative regulation of fat cell differentiation [ISS]
- negative regulation of oligodendrocyte progenitor proliferation [ISS]
- negative regulation of peptidyl-threonine phosphorylation [ISS]
- negative regulation of protein catabolic process [IMP]
- negative regulation of reactive oxygen species metabolic process [ISS]
- negative regulation of striated muscle tissue development [IDA]
- negative regulation of transcription from RNA polymerase II promoter [IDA, IMP]
- negative regulation of transcription from RNA polymerase II promoter in response to hypoxia [IMP]
- negative regulation of transcription, DNA-templated [IDA]
- peptidyl-lysine deacetylation [IDA]
- phosphatidylinositol 3-kinase signaling [IMP]
- positive regulation of DNA binding [ISS]
- positive regulation of attachment of spindle microtubules to kinetochore [ISS]
- positive regulation of cell division [ISS]
- positive regulation of execution phase of apoptosis [ISS]
- positive regulation of meiosis [ISS]
- positive regulation of oocyte maturation [ISS]
- positive regulation of proteasomal ubiquitin-dependent protein catabolic process [ISS]
- positive regulation of proteasomal ubiquitin-dependent protein catabolic process involved in cellular response to hypoxia [IMP]
- positive regulation of transcription from RNA polymerase II promoter [ISS]
- proteasome-mediated ubiquitin-dependent protein catabolic process [IMP]
- protein ADP-ribosylation [NAS, TAS]
- protein deacetylation [IDA, IMP]
- protein kinase B signaling [IMP]
- regulation of cell cycle [IMP]
- regulation of exit from mitosis [NAS]
- regulation of myelination [ISS]
- regulation of phosphorylation [NAS]
- response to redox state [NAS]
- substantia nigra development [IEP]
- tubulin deacetylation [IDA, IMP, ISS]
Gene Ontology Molecular Function- NAD+ ADP-ribosyltransferase activity [TAS]
- NAD+ binding [IDA]
- NAD-dependent histone deacetylase activity [IDA]
- NAD-dependent histone deacetylase activity (H4-K16 specific) [IDA]
- NAD-dependent protein deacetylase activity [IDA, IMP]
- chromatin binding [IDA]
- histone acetyltransferase binding [IPI]
- histone deacetylase activity [IDA]
- histone deacetylase binding [IPI]
- protein binding [IPI]
- protein deacetylase activity [IDA, IMP]
- transcription factor binding [IPI]
- tubulin deacetylase activity [IDA]
- ubiquitin binding [IDA]
- zinc ion binding [IDA]
- NAD+ ADP-ribosyltransferase activity [TAS]
- NAD+ binding [IDA]
- NAD-dependent histone deacetylase activity [IDA]
- NAD-dependent histone deacetylase activity (H4-K16 specific) [IDA]
- NAD-dependent protein deacetylase activity [IDA, IMP]
- chromatin binding [IDA]
- histone acetyltransferase binding [IPI]
- histone deacetylase activity [IDA]
- histone deacetylase binding [IPI]
- protein binding [IPI]
- protein deacetylase activity [IDA, IMP]
- transcription factor binding [IPI]
- tubulin deacetylase activity [IDA]
- ubiquitin binding [IDA]
- zinc ion binding [IDA]
Gene Ontology Cellular Component
- Schmidt-Lanterman incisure [ISS]
- centriole [IDA]
- centrosome [IDA]
- chromatin silencing complex [NAS]
- chromosome [IDA]
- cytoplasm [IDA]
- cytosol [IDA]
- glial cell projection [ISS]
- juxtaparanode region of axon [ISS]
- lateral loop [ISS]
- meiotic spindle [ISS]
- microtubule [IDA]
- midbody [IDA]
- mitotic spindle [IDA]
- myelin sheath [ISS]
- nuclear heterochromatin [ISS]
- nucleus [IDA]
- paranodal junction [ISS]
- paranode region of axon [ISS]
- perikaryon [ISS]
- perinuclear region of cytoplasm [ISS]
- spindle [IDA]
Homo sapiens
PREY
MCL1
BCL2L3, EAT, MCL1-ES, MCL1L, MCL1S, Mcl-1, TM, bcl2-L-3, mcl1/EAT
myeloid cell leukemia 1
GO Process (11)
GO Function (5)
GO Component (7)
Gene Ontology Biological Process
- cell fate determination [NAS]
- cellular homeostasis [NAS]
- extrinsic apoptotic signaling pathway in absence of ligand [IMP]
- intrinsic apoptotic signaling pathway in response to DNA damage [IBA]
- negative regulation of anoikis [IMP]
- negative regulation of extrinsic apoptotic signaling pathway in absence of ligand [IMP]
- negative regulation of intrinsic apoptotic signaling pathway [IBA]
- positive regulation of oxidative stress-induced neuron intrinsic apoptotic signaling pathway [IGI]
- protein transmembrane transport [TAS]
- regulation of response to DNA damage stimulus [IMP]
- response to cytokine [IDA]
Gene Ontology Molecular Function
Homo sapiens
Biochemical Activity (Deacetylation)
An interaction is inferred from the biochemical effect of one protein upon another, for example, GTP-GDP exchange activity or phosphorylation of a substrate by a kinase. The bait protein executes the activity on the substrate hit protein. A Modification value is recorded for interactions of this type with the possible values Phosphorylation, Ubiquitination, Sumoylation, Dephosphorylation, Methylation, Prenylation, Acetylation, Deubiquitination, Proteolytic Processing, Glucosylation, Nedd(Rub1)ylation, Deacetylation, No Modification, Demethylation.
Publication
Interplay between protein acetylation and ubiquitination controls MCL1 protein stability.
The anti-apoptotic myeloid cell leukemia 1 (MCL1) protein belongs to the pro-survival BCL2 family and is frequently amplified or elevated in human cancers. MCL1 is highly unstable, with its stability being regulated by phosphorylation and ubiquitination. Here, we identify acetylation as another critical post-translational modification regulating MCL1 protein stability. We demonstrate that the lysine acetyltransferase p300 targets MCL1 at K40 ... [more]
Cell Rep Dec. 09, 2020; 37(6);109988 [Pubmed: 34758305]
Throughput
- Low Throughput
Curated By
- BioGRID