BAIT
PRAMEF2
DJ845O24.3, RP5-845O24.1
PRAME family member 2
GO Process (0)
GO Function (0)
GO Component (0)
Homo sapiens
PREY
ANXA1
ANX1, LPC1, RP11-71A24.1
annexin A1
GO Process (12)
GO Function (8)
GO Component (11)
Gene Ontology Biological Process
- alpha-beta T cell differentiation [ISS]
- cellular component movement [TAS]
- cellular response to glucocorticoid stimulus [IDA]
- inflammatory response [TAS]
- keratinocyte differentiation [IDA]
- negative regulation of apoptotic process [TAS]
- negative regulation of interleukin-8 secretion [IMP]
- neutrophil clearance [IMP]
- neutrophil homeostasis [IMP]
- peptide cross-linking [IDA]
- positive regulation of vesicle fusion [IDA]
- signal transduction [TAS]
Gene Ontology Molecular Function
Gene Ontology Cellular Component
Homo sapiens
Affinity Capture-MS
An interaction is inferred when a bait protein is affinity captured from cell extracts by either polyclonal antibody or epitope tag and the associated interaction partner is identified by mass spectrometric methods.
Publication
PRAMEF2-mediated dynamic regulation of YAP signaling promotes tumorigenesis.
PRAMEF2 is a member of the PRAME multigene family of cancer testis antigens, which serve as prognostic markers for several cancers. However, molecular mechanisms underlying its role in tumorigenesis remain poorly understood. Here, we report that PRAMEF2 is repressed under conditions of altered metabolic homeostasis in a FOXP3-dependent manner. We further demonstrate that PRAMEF2 is a BC-box containing substrate recognition ... [more]
Proc Natl Acad Sci U S A Dec. 05, 2020; 118(40); [Pubmed: 34593639]
Throughput
- High Throughput
Curated By
- BioGRID