REV1
Gene Ontology Biological Process
Gene Ontology Molecular Function
Gene Ontology Cellular Component
DOT1
Gene Ontology Biological Process
- DNA damage checkpoint [IGI, IMP]
- G1 DNA damage checkpoint [IMP]
- chromatin silencing at telomere [IMP]
- global genome nucleotide-excision repair [IMP]
- histone H3-K79 methylation [IDA, IMP]
- intra-S DNA damage checkpoint [IMP]
- meiotic recombination checkpoint [IGI]
- nucleotide-excision repair [IGI, IMP]
- postreplication repair [IGI]
- recombinational repair [IGI, IMP]
Gene Ontology Molecular Function
Synthetic Growth Defect
A genetic interaction is inferred when mutations in separate genes, each of which alone causes a minimal phenotype, result in a significant growth defect under a given condition when combined in the same cell.
Publication
Role of Dot1 in the response to alkylating DNA damage in Saccharomyces cerevisiae: regulation of DNA damage tolerance by the error-prone polymerases Polzeta/Rev1.
Maintenance of genomic integrity relies on a proper response to DNA injuries integrated by the DNA damage checkpoint; histone modifications play an important role in this response. Dot1 methylates lysine 79 of histone H3. In Saccharomyces cerevisiae, Dot1 is required for the meiotic recombination checkpoint as well as for chromatin silencing and the G(1)/S and intra-S DNA damage checkpoints in ... [more]
Throughput
- Low Throughput
Ontology Terms
- phenotype: vegetative growth (APO:0000106)
- phenotype: resistance to chemicals (APO:0000087)
Related interactions
Interaction | Experimental Evidence Code | Dataset | Throughput | Score | Curated By | Notes |
---|---|---|---|---|---|---|
DOT1 REV1 | Phenotypic Enhancement Phenotypic Enhancement A genetic interaction is inferred when mutation or overexpression of one gene results in enhancement of any phenotype (other than lethality/growth defect) associated with mutation or over expression of another gene. | Low | - | BioGRID | 239386 | |
DOT1 REV1 | Synthetic Growth Defect Synthetic Growth Defect A genetic interaction is inferred when mutations in separate genes, each of which alone causes a minimal phenotype, result in a significant growth defect under a given condition when combined in the same cell. | Low | - | BioGRID | 459051 |
Curated By
- BioGRID