MFT1
Gene Ontology Biological Process
Gene Ontology Molecular Function
Gene Ontology Cellular Component
CTK1
Gene Ontology Biological Process
- mRNA 3'-end processing [IGI, IMP]
- peptidyl-serine phosphorylation [IDA]
- phosphorylation of RNA polymerase II C-terminal domain [IMP]
- positive regulation of DNA-templated transcription, elongation [IDA]
- positive regulation of transcription from RNA polymerase I promoter [IMP]
- positive regulation of translational fidelity [IMP]
- protein phosphorylation [IDA, IMP, ISS]
Gene Ontology Molecular Function
Gene Ontology Cellular Component
Synthetic Lethality
A genetic interaction is inferred when mutations or deletions in separate genes, each of which alone causes a minimal phenotype, result in lethality when combined in the same cell under a given condition.
Publication
Nuclear mRNA surveillance in THO/sub2 mutants is triggered by inefficient polyadenylation.
The yeast THO complex and the associated RNA helicase Sub2p are important mRNP maturation factors. Transcripts produced in THO/sub2 mutants are subject to degradation by a surveillance mechanism that involves the nuclear RNA exosome. Here we show that inefficient polyadenylation forms the basis of this accelerated mRNA decay. A genetic screen reveals extensive interactions between deletions of THO subunits and ... [more]
Throughput
- Low Throughput
Ontology Terms
- phenotype: inviable (APO:0000112)
Related interactions
| Interaction | Experimental Evidence Code | Dataset | Throughput | Score | Curated By | Notes |
|---|---|---|---|---|---|---|
| MFT1 CTK1 | Synthetic Lethality Synthetic Lethality A genetic interaction is inferred when mutations or deletions in separate genes, each of which alone causes a minimal phenotype, result in lethality when combined in the same cell under a given condition. | Low | - | BioGRID | 162206 |
Curated By
- BioGRID