BAIT
CANX
CNX, IP90, P90
calnexin
GO Process (9)
GO Function (2)
GO Component (7)
Gene Ontology Biological Process
- antigen processing and presentation of exogenous peptide antigen via MHC class II [TAS]
- antigen processing and presentation of peptide antigen via MHC class I [TAS]
- cellular protein metabolic process [TAS]
- clathrin-mediated endocytosis [ISS]
- post-translational protein modification [TAS]
- protein N-linked glycosylation via asparagine [TAS]
- protein folding [TAS]
- protein secretion [TAS]
- synaptic vesicle endocytosis [ISS]
Gene Ontology Molecular Function
Homo sapiens
PREY
WNT11
HWNT11
wingless-type MMTV integration site family, member 11
GO Process (27)
GO Function (4)
GO Component (3)
Gene Ontology Biological Process
- adrenal gland development [IEP]
- cell fate commitment [IBA]
- cellular response to retinoic acid [ISS]
- cloacal septation [IEP]
- embryonic skeletal system development [IEP]
- lung-associated mesenchyme development [IEP]
- mesonephric duct development [IEP]
- negative regulation of apoptotic process [IMP]
- negative regulation of canonical Wnt signaling pathway [IMP]
- negative regulation of cartilage development [NAS]
- negative regulation of cell death [IMP]
- negative regulation of cell growth [IMP]
- negative regulation of cell migration [IMP]
- negative regulation of transcription, DNA-templated [IMP]
- neuroendocrine cell differentiation [IMP]
- neuron differentiation [IBA, ISS]
- palate development [IMP]
- positive regulation of Ras GTPase activity [IMP]
- positive regulation of cell migration [IMP]
- positive regulation of gene expression [IMP]
- positive regulation of protein kinase C signaling [IMP]
- positive regulation of protein kinase activity [IMP]
- positive regulation of stress fiber assembly [IMP]
- positive regulation of transcription, DNA-templated [IMP]
- protein localization to cell surface [IMP]
- protein phosphorylation [IMP]
- ureteric bud morphogenesis [IEP]
Gene Ontology Molecular Function
Gene Ontology Cellular Component
Homo sapiens
Affinity Capture-MS
An interaction is inferred when a bait protein is affinity captured from cell extracts by either polyclonal antibody or epitope tag and the associated interaction partner is identified by mass spectrometric methods.
Publication
OpenCell: Endogenous tagging for the cartography of human cellular organization.
Elucidating the wiring diagram of the human cell is a central goal of the postgenomic era. We combined genome engineering, confocal live-cell imaging, mass spectrometry, and data science to systematically map the localization and interactions of human proteins. Our approach provides a data-driven description of the molecular and spatial networks that organize the proteome. Unsupervised clustering of these networks delineates ... [more]
Science Dec. 11, 2021; 375(6585);eabi6983 [Pubmed: 35271311]
Throughput
- High Throughput
Additional Notes
- Bait generated from library of CRISPR-edited human embryonic kidney (HEK) 293T cell lines harboring fluorescent tags on individual proteins
Curated By
- BioGRID