CANX
Gene Ontology Biological Process
- antigen processing and presentation of exogenous peptide antigen via MHC class II [TAS]
- antigen processing and presentation of peptide antigen via MHC class I [TAS]
- cellular protein metabolic process [TAS]
- clathrin-mediated endocytosis [ISS]
- post-translational protein modification [TAS]
- protein N-linked glycosylation via asparagine [TAS]
- protein folding [TAS]
- protein secretion [TAS]
- synaptic vesicle endocytosis [ISS]
Gene Ontology Molecular Function
CXADR
Gene Ontology Biological Process
- AV node cell to bundle of His cell communication [ISS]
- actin cytoskeleton reorganization [IDA]
- blood coagulation [TAS]
- cardiac muscle fiber development [ISS]
- cell-cell junction organization [ISS]
- defense response to virus [IDA]
- epithelial structure maintenance [IMP]
- gamma-delta T cell activation [ISS]
- germ cell migration [ISS]
- heart development [ISS]
- heterophilic cell-cell adhesion via plasma membrane cell adhesion molecules [IDA]
- homotypic cell-cell adhesion [IDA]
- leukocyte migration [TAS]
- mitochondrion organization [ISS]
- neutrophil chemotaxis [IMP]
- regulation of immune response [TAS]
- transepithelial transport [IMP]
Gene Ontology Molecular Function
Gene Ontology Cellular Component
- acrosomal vesicle [ISS]
- adherens junction [IDA]
- apicolateral plasma membrane [IDA]
- basolateral plasma membrane [IDA]
- cell body [ISS]
- cell junction [IDA]
- cell-cell junction [IDA]
- extracellular space [IDA]
- filopodium [ISS]
- growth cone [ISS]
- integral component of plasma membrane [NAS]
- intercalated disc [IDA]
- membrane raft [IDA]
- neuromuscular junction [IDA]
- neuron projection [ISS]
- nucleoplasm [IDA]
- plasma membrane [IDA, TAS]
- protein complex [IDA]
- tight junction [IDA]
Affinity Capture-MS
An interaction is inferred when a bait protein is affinity captured from cell extracts by either polyclonal antibody or epitope tag and the associated interaction partner is identified by mass spectrometric methods.
Publication
OpenCell: Endogenous tagging for the cartography of human cellular organization.
Elucidating the wiring diagram of the human cell is a central goal of the postgenomic era. We combined genome engineering, confocal live-cell imaging, mass spectrometry, and data science to systematically map the localization and interactions of human proteins. Our approach provides a data-driven description of the molecular and spatial networks that organize the proteome. Unsupervised clustering of these networks delineates ... [more]
Throughput
- High Throughput
Additional Notes
- Bait generated from library of CRISPR-edited human embryonic kidney (HEK) 293T cell lines harboring fluorescent tags on individual proteins
Related interactions
| Interaction | Experimental Evidence Code | Dataset | Throughput | Score | Curated By | Notes |
|---|---|---|---|---|---|---|
| CXADR CANX | Proximity Label-MS Proximity Label-MS An interaction is inferred when a bait-enzyme fusion protein selectively modifies a vicinal protein with a diffusible reactive product, followed by affinity capture of the modified protein and identification by mass spectrometric methods. | High | 9.91 | BioGRID | 2984857 |
Curated By
- BioGRID