RAB3GAP2
Gene Ontology Biological Process
- establishment of protein localization to endoplasmic reticulum membrane [IMP]
- intracellular protein transport [TAS]
- positive regulation of GTPase activity [TAS]
- positive regulation of Rab GTPase activity [IMP]
- positive regulation of catalytic activity [TAS]
- positive regulation of endoplasmic reticulum tubular network organization [IMP]
- regulation of GTPase activity [ISS]
Gene Ontology Molecular Function
Gene Ontology Cellular Component
RAB3GAP1
Gene Ontology Biological Process
- brain development [IMP]
- camera-type eye development [IMP]
- establishment of protein localization to endoplasmic reticulum membrane [IMP]
- face morphogenesis [IMP]
- hypothalamus development [IMP]
- lipid particle organization [IMP]
- positive regulation of GTP catabolic process [IMP]
- positive regulation of Rab GTPase activity [IMP, ISS]
- positive regulation of endoplasmic reticulum tubular network organization [IMP]
- positive regulation of glutamate neurotransmitter secretion in response to membrane depolarization [ISS]
- regulation of GTPase activity [IDA]
- regulation of calcium ion-dependent exocytosis of neurotransmitter [ISS]
- regulation of excitatory postsynaptic membrane potential [ISS]
- regulation of short-term neuronal synaptic plasticity [ISS]
Gene Ontology Molecular Function
Gene Ontology Cellular Component
Affinity Capture-MS
An interaction is inferred when a bait protein is affinity captured from cell extracts by either polyclonal antibody or epitope tag and the associated interaction partner is identified by mass spectrometric methods.
Publication
OpenCell: Endogenous tagging for the cartography of human cellular organization.
Elucidating the wiring diagram of the human cell is a central goal of the postgenomic era. We combined genome engineering, confocal live-cell imaging, mass spectrometry, and data science to systematically map the localization and interactions of human proteins. Our approach provides a data-driven description of the molecular and spatial networks that organize the proteome. Unsupervised clustering of these networks delineates ... [more]
Throughput
- High Throughput
Additional Notes
- Bait generated from library of CRISPR-edited human embryonic kidney (HEK) 293T cell lines harboring fluorescent tags on individual proteins
Related interactions
| Interaction | Experimental Evidence Code | Dataset | Throughput | Score | Curated By | Notes |
|---|---|---|---|---|---|---|
| RAB3GAP1 RAB3GAP2 | Affinity Capture-Western Affinity Capture-Western An interaction is inferred when a bait protein is affinity captured from cell extracts by either polyclonal antibody or epitope tag and the associated interaction partner identified by Western blot with a specific polyclonal antibody or second epitope tag. This category is also used if an interacting protein is visualized directly by dye stain or radioactivity. Note that this differs from any co-purification experiment involving affinity capture in that the co-purification experiment involves at least one extra purification step to get rid of potential contaminating proteins. | Low | - | BioGRID | - | |
| RAB3GAP1 RAB3GAP2 | Co-fractionation Co-fractionation Interaction inferred from the presence of two or more protein subunits in a partially purified protein preparation. If co-fractionation is demonstrated between 3 or more proteins, then add them as a complex. | High | - | BioGRID | 924489 | |
| RAB3GAP2 RAB3GAP1 | Co-fractionation Co-fractionation Interaction inferred from the presence of two or more protein subunits in a partially purified protein preparation. If co-fractionation is demonstrated between 3 or more proteins, then add them as a complex. | High | 0.9506 | BioGRID | 1268543 |
Curated By
- BioGRID