GPA2
Gene Ontology Biological Process
Gene Ontology Molecular Function
Gene Ontology Cellular Component
GPA1
Gene Ontology Biological Process
- adaptation of signaling pathway by response to pheromone involved in conjugation with cellular fusion [IMP]
- adenylate cyclase-activating G-protein coupled receptor signaling pathway [IBA]
- heterotrimeric G-protein complex cycle [IMP]
- inositol lipid-mediated signaling [IMP]
- karyogamy involved in conjugation with cellular fusion [IMP]
- nuclear migration involved in conjugation with cellular fusion [IMP]
- pheromone-dependent signal transduction involved in conjugation with cellular fusion [IMP]
- regulation of MAPK export from nucleus [IMP]
Gene Ontology Molecular Function
Gene Ontology Cellular Component
FRET
An interaction is inferred when close proximity of interaction partners is detected by fluorescence resonance energy transfer between pairs of fluorophore-labeled molecules, such as occurs between CFP (donor) and YFP (acceptor) fusion proteins.
Publication
Endosomal cargo recycling mediated by Gpa1 and phosphatidylinositol 3-kinase is inhibited by glucose starvation.
Cell surface protein trafficking is regulated in response to nutrient availability, with multiple pathways directing surface membrane proteins to the lysosome for degradation in response to suboptimal extracellular nutrients. Internalized protein and lipid cargoes recycle back to the surface efficiently in glucose-replete conditions, but this trafficking is attenuated following glucose starvation. We find that cells with either reduced or hyperactive ... [more]
Throughput
- Low Throughput
Related interactions
Interaction | Experimental Evidence Code | Dataset | Throughput | Score | Curated By | Notes |
---|---|---|---|---|---|---|
GPA2 GPA1 | Affinity Capture-MS Affinity Capture-MS An interaction is inferred when a bait protein is affinity captured from cell extracts by either polyclonal antibody or epitope tag and the associated interaction partner is identified by mass spectrometric methods. | High | - | BioGRID | - | |
GPA2 GPA1 | Synthetic Lethality Synthetic Lethality A genetic interaction is inferred when mutations or deletions in separate genes, each of which alone causes a minimal phenotype, result in lethality when combined in the same cell under a given condition. | Low | - | BioGRID | 158107 |
Curated By
- BioGRID