BAIT

AURKA

AIK, ARK1, AURA, AURORA2, BTAK, PPP1R47, STK15, STK6, STK7, RP5-1167H4.6
aurora kinase A
Human Papilloma Virus (HPV) Project
Synthetic Protein Interaction Project
Homo sapiens
PREY

MRPL24

L24mt, MRP-L18, MRP-L24
mitochondrial ribosomal protein L24
GO Process (0)
GO Function (0)
GO Component (0)
Homo sapiens

Affinity Capture-MS

An interaction is inferred when a bait protein is affinity captured from cell extracts by either polyclonal antibody or epitope tag and the associated interaction partner is identified by mass spectrometric methods.

Publication

PROTAC-mediated degradation reveals a non-catalytic function of AURORA-A kinase.

Adhikari B, Bozilovic J, Diebold M, Schwarz JD, Hofstetter J, Schroeder M, Wanior M, Narain A, Vogt M, Dudvarski Stankovic N, Baluapuri A, Schoenemann L, Eing L, Bhandare P, Kuster B, Schlosser A, Heinzlmeir S, Sotriffer C, Knapp S, Wolf E

The mitotic kinase AURORA-A is essential for cell cycle progression and is considered a priority cancer target. Although the catalytic activity of AURORA-A is essential for its mitotic function, recent reports indicate an additional non-catalytic function, which is difficult to target by conventional small molecules. We therefore developed a series of chemical degraders (PROTACs) by connecting a clinical kinase inhibitor ... [more]

Nat Chem Biol Dec. 01, 2019; 16(11);1179-1188 [Pubmed: 32989298]

Throughput

  • High Throughput

Related interactions

InteractionExperimental Evidence CodeDatasetThroughputScoreCurated ByNotes
AURKA MRPL24
Affinity Capture-MS
Affinity Capture-MS

An interaction is inferred when a bait protein is affinity captured from cell extracts by either polyclonal antibody or epitope tag and the associated interaction partner is identified by mass spectrometric methods.

High-BioGRID
-

Curated By

  • BioGRID