BAIT

KDM6A

KABUK2, UTX, bA386N14.2, RP13-886N14.3
lysine (K)-specific demethylase 6A
GO Process (1)
GO Function (0)
GO Component (2)

Gene Ontology Biological Process

Gene Ontology Cellular Component

Homo sapiens
PREY

PROSER1

C13orf23, RP11-50D16.2
proline and serine rich 1
GO Process (0)
GO Function (0)
GO Component (0)
Homo sapiens

Affinity Capture-MS

An interaction is inferred when a bait protein is affinity captured from cell extracts by either polyclonal antibody or epitope tag and the associated interaction partner is identified by mass spectrometric methods.

Publication

Demethylation of H3K27 regulates polycomb recruitment and H2A ubiquitination.

Lee MG, Villa R, Trojer P, Norman J, Yan KP, Reinberg D, Di Croce L, Shiekhattar R

Methylation of histone H3 lysine 27 (H3K27) is a posttranslational modification that is highly correlated with genomic silencing. Here we show that human UTX, a member of the Jumonji C family of proteins, is a di- and trimethyl H3K27 demethylase. UTX occupies the promoters of HOX gene clusters and regulates their transcriptional output by modulating the recruitment of polycomb repressive ... [more]

Science Oct. 19, 2007; 318(5849);447-50 [Pubmed: 17761849]

Throughput

  • Low Throughput

Curated By

  • BioGRID