BAIT
SLC1A2
1700091C19Rik, 2900019G14Rik, AI159670, Eaat2, GLT-1, GLT1, MGLT1, RP23-163L4.1
solute carrier family 1 (glial high affinity glutamate transporter), member 2
GO Process (17)
GO Function (3)
GO Component (9)
Gene Ontology Biological Process
- D-aspartate import [ISO]
- L-glutamate import [ISO]
- L-glutamate transmembrane transport [IMP, ISO]
- L-glutamate transport [IDA, IMP, ISO]
- adult behavior [IMP]
- cellular response to extracellular stimulus [IMP]
- multicellular organism growth [IMP]
- multicellular organismal aging [IMP]
- nervous system development [IMP]
- positive regulation of glucose import [IMP]
- response to amino acid [IMP]
- response to drug [IMP]
- response to light stimulus [IMP]
- response to wounding [IMP]
- sodium ion transmembrane transport [ISO]
- telencephalon development [IMP]
- visual behavior [IMP]
Gene Ontology Molecular Function
Gene Ontology Cellular Component
Mus musculus
PREY
CD74
CLIP, DHLAG, HLADG, Ia-GAMMA, Ii
CD74 antigen (invariant polypeptide of major histocompatibility complex, class II antigen-associated)
GO Process (35)
GO Function (10)
GO Component (17)
Gene Ontology Biological Process
- activation of MAPK activity [ISO]
- antigen processing and presentation [IDA, IMP]
- antigen processing and presentation of exogenous peptide antigen via MHC class II [IMP]
- cell proliferation [ISO]
- chaperone mediated protein folding requiring cofactor [IDA, IMP]
- cytokine-mediated signaling pathway [IMP]
- defense response [IMP]
- immunoglobulin mediated immune response [IMP]
- intracellular protein transport [IDA, IMP]
- macrophage migration inhibitory factor signaling pathway [IDA]
- negative regulation of DNA damage response, signal transduction by p53 class mediator [IMP, ISO]
- negative regulation of T cell differentiation [IMP]
- negative regulation of apoptotic process [ISO]
- negative regulation of intrinsic apoptotic signaling pathway in response to DNA damage by p53 class mediator [IMP, ISO]
- negative regulation of mature B cell apoptotic process [IMP]
- negative regulation of peptide secretion [ISO]
- negative thymic T cell selection [IMP]
- positive regulation of B cell proliferation [ISO]
- positive regulation of ERK1 and ERK2 cascade [IMP, ISO]
- positive regulation of T cell differentiation [IMP]
- positive regulation of adaptive immune response [NAS]
- positive regulation of chemokine (C-X-C motif) ligand 2 production [IDA]
- positive regulation of cytokine-mediated signaling pathway [IMP, ISO]
- positive regulation of dendritic cell antigen processing and presentation [IDA]
- positive regulation of fibroblast proliferation [ISO]
- positive regulation of innate immune response [IC]
- positive regulation of macrophage cytokine production [IDA]
- positive regulation of neutrophil chemotaxis [IDA]
- positive regulation of peptidyl-tyrosine phosphorylation [IMP, ISO]
- positive regulation of type 2 immune response [IMP]
- positive thymic T cell selection [IMP]
- prostaglandin biosynthetic process [ISO]
- protein complex assembly [IDA]
- protein folding [ISO]
- signal transduction [ISO]
Gene Ontology Molecular Function- MHC class II protein binding [IPI]
- MHC class II protein binding, via antigen binding groove [ISO]
- MHC class II protein complex binding [ISO]
- beta-amyloid binding [ISO]
- cytokine binding [IDA, ISO]
- cytokine receptor activity [IMP, ISO]
- macrophage migration inhibitory factor binding [ISO]
- nitric-oxide synthase binding [IPI]
- protein binding [IPI]
- protein binding involved in protein folding [ISO]
- MHC class II protein binding [IPI]
- MHC class II protein binding, via antigen binding groove [ISO]
- MHC class II protein complex binding [ISO]
- beta-amyloid binding [ISO]
- cytokine binding [IDA, ISO]
- cytokine receptor activity [IMP, ISO]
- macrophage migration inhibitory factor binding [ISO]
- nitric-oxide synthase binding [IPI]
- protein binding [IPI]
- protein binding involved in protein folding [ISO]
Gene Ontology Cellular Component
- Golgi apparatus [IDA]
- MHC class II protein complex [IDA]
- NOS2-CD74 complex [IDA]
- cell surface [ISO]
- endoplasmic reticulum [IDA]
- external side of plasma membrane [IDA]
- extracellular vesicular exosome [ISO]
- integral component of membrane [ISO]
- integral component of plasma membrane [TAS]
- intracellular [IMP]
- late endosome [IDA]
- lysosome [IDA]
- macrophage migration inhibitory factor receptor complex [IDA, ISO]
- membrane [ISO]
- multivesicular body [IDA]
- plasma membrane [IDA, IMP]
- vacuole [ISO]
Mus musculus
Affinity Capture-MS
An interaction is inferred when a bait protein is affinity captured from cell extracts by either polyclonal antibody or epitope tag and the associated interaction partner is identified by mass spectrometric methods.
Publication
Identification by proximity labeling of novel lipidic and proteinaceous potential partners of the dopamine transporter.
Dopamine (DA) transporters (DATs) are regulated by trafficking and modulatory processes that probably rely on stable and transient interactions with neighboring proteins and lipids. Using proximity-dependent biotin identification (BioID), we found novel potential partners for DAT, including several membrane proteins, such as the transmembrane chaperone 4F2hc, the proteolipid M6a and a potential membrane receptor for progesterone (PGRMC2). We also detected ... [more]
Cell Mol Life Sci Dec. 01, 2021; 78(23);7733-7756 [Pubmed: 34709416]
Throughput
- Low Throughput
Additional Notes
- BioID
Curated By
- BioGRID