BAIT
RGS4
RGP4, SCZD9, RP11-430G6.1
regulator of G-protein signaling 4
GO Process (2)
GO Function (2)
GO Component (2)
Gene Ontology Biological Process
Gene Ontology Molecular Function
Gene Ontology Cellular Component
Homo sapiens
PREY
UBR1
JBS
ubiquitin protein ligase E3 component n-recognin 1
GO Process (2)
GO Function (1)
GO Component (0)
Gene Ontology Biological Process
Gene Ontology Molecular Function
Homo sapiens
Protein-peptide
An interaction is detected between a protein and a peptide derived from an interaction partner. This includes phage display experiments.
Publication
The N-terminal cysteine is a dual sensor of oxygen and oxidative stress.
Cellular homeostasis requires the sensing of and adaptation to intracellular oxygen (O2) and reactive oxygen species (ROS). The Arg/N-degron pathway targets proteins that bear destabilizing N-terminal residues for degradation by the proteasome or via autophagy. Under normoxic conditions, the N-terminal Cys (Nt-Cys) residues of specific substrates can be oxidized by dioxygenases such as plant cysteine oxidases and cysteamine (2-aminoethanethiol) dioxygenases ... [more]
Proc Natl Acad Sci U S A Dec. 14, 2020; 118(50); [Pubmed: 34893540]
Throughput
- Low Throughput
Curated By
- BioGRID