BAIT
UGO1
YDR470C
Outer membrane component of the mitochondrial fusion machinery; binds directly to Fzo1p and Mgm1p and thus links these two GTPases during mitochondrial fusion; involved in fusion of both the outer and inner membranes; facilitates dimerization of Fzo1p during fusion; import into the outer membrane is mediated by Tom70p and Mim1p; has similarity to carrier proteins but is not likely to function as a transmembrane transporter
GO Process (1)
GO Function (0)
GO Component (3)
Gene Ontology Biological Process
Gene Ontology Cellular Component
Saccharomyces cerevisiae (S288c)
PREY
YPL109C
Putative protein of unknown function; the authentic, non-tagged protein is detected in highly purified mitochondria in high-throughput studies
GO Process (0)
GO Function (0)
GO Component (1)
Gene Ontology Cellular Component
Saccharomyces cerevisiae (S288c)
Dosage Rescue
A genetic interaction is inferred when over expression or increased dosage of one gene rescues the lethality or growth defect of a strain that is mutated or deleted for another gene.
Publication
A hunt for OM45 synthetic petite interactions in Saccharomyces cerevisiae reveals a role for Miro GTPase Gem1p in cristae structure maintenance.
Om45 is a major protein of the yeast's outer mitochondrial membrane under respiratory conditions. However, the cellular role of the protein has remained obscure. Previously, deletion mutant phenotypes have not been found, and clear amino acid sequence similarities that would allow inferring its functional role are not available. In this work, we describe synthetic petite mutants of GEM1 and UGO1 ... [more]
Microbiologyopen Dec. 01, 2020; 10(5);e1238 [Pubmed: 34713605]
Throughput
- Low Throughput
Ontology Terms
- phenotype: respiratory growth (APO:0000309)
Additional Notes
- Respiratory growth of om45/ugo1 and om45/gem1 mutant SPMs was restored by multicopy plasmids carrying MCP1, PET54 and YPL109c
- genetic complex
Curated By
- BioGRID