ASH1
Gene Ontology Biological Process
- negative regulation of G1/S transition of mitotic cell cycle by negative regulation of transcription from RNA polymerase II promoter [IDA, IMP]
- negative regulation of mating type switching by negative regulation of transcription from RNA polymerase II promoter [IMP]
- positive regulation of pseudohyphal growth by positive regulation of transcription from RNA polymerase II promoter [IMP]
Gene Ontology Molecular Function
Gene Ontology Cellular Component
TUP1
Gene Ontology Biological Process
- histone exchange [IMP]
- negative regulation of dipeptide transport by negative regulation of transcription from RNA polymerase II promoter [IMP]
- negative regulation of mating-type specific transcription from RNA polymerase II promoter [IMP]
- negative regulation of transcription from RNA polymerase II promoter [IMP]
- negative regulation of transcription from RNA polymerase II promoter by glucose [IMP]
- negative regulation of transcription from RNA polymerase II promoter during mitosis [IMP]
- nucleosome positioning [IDA]
- regulation of fatty acid biosynthetic process by regulation of transcription from RNA polymerase II promoter [IMP]
- regulation of invasive growth in response to glucose limitation [IMP]
- regulation of response to DNA damage stimulus [IMP]
Gene Ontology Molecular Function- RNA polymerase II transcription factor binding transcription factor activity involved in negative regulation of transcription [IDA, IMP]
- histone binding [IDA]
- histone deacetylase binding [IDA, IPI]
- mediator complex binding [IDA, IPI]
- phosphatidylinositol-3,5-bisphosphate binding [IDA]
- ubiquitin binding [IDA]
- RNA polymerase II transcription factor binding transcription factor activity involved in negative regulation of transcription [IDA, IMP]
- histone binding [IDA]
- histone deacetylase binding [IDA, IPI]
- mediator complex binding [IDA, IPI]
- phosphatidylinositol-3,5-bisphosphate binding [IDA]
- ubiquitin binding [IDA]
Gene Ontology Cellular Component
Phenotypic Suppression
A genetic interaction is inferred when mutation or over expression of one gene results in suppression of any phenotype (other than lethality/growth defect) associated with mutation or over expression of another gene.
Publication
Genetic analysis argues for a coactivator function for the Saccharomyces cerevisiae Tup1 corepressor.
The Tup1-Cyc8 corepressor complex of Saccharomyces cerevisiae is recruited to promoters by DNA-binding proteins to repress transcription of genes, including the a-specific mating-type genes. We report here a tup1(S649F) mutant that displays mating irregularities and an ?-predominant growth defect. RNA-Seq and ChIP-Seq were used to analyze gene expression and Tup1 occupancy changes in mutant vs wild type in both a ... [more]
Throughput
- Low Throughput
Ontology Terms
- rna accumulation (APO:0000224)
Additional Notes
- Figure 3
- genetic complex
- multiple tup1 alleles
- tup1 mutation in swi5 ash1 double mutant increases HO RNA expression
Related interactions
| Interaction | Experimental Evidence Code | Dataset | Throughput | Score | Curated By | Notes |
|---|---|---|---|---|---|---|
| ASH1 TUP1 | Phenotypic Enhancement Phenotypic Enhancement A genetic interaction is inferred when mutation or overexpression of one gene results in enhancement of any phenotype (other than lethality/growth defect) associated with mutation or over expression of another gene. | Low | - | BioGRID | 2562049 |
Curated By
- BioGRID