BAIT

BAG3

BAG-3, BIS, CAIR-1, MFM6

BCL2-associated athanogene 3

Alzheimer's Disease Project

GO Process (3)

GO Function (1)

GO Component (3)

Gene Ontology Biological Process

extrinsic apoptotic signaling pathway via death domain receptors [IDA]

negative regulation of apoptotic process [NAS]

protein folding [NAS]

Gene Ontology Molecular Function

protein binding [IPI]

Gene Ontology Cellular Component

cytoplasm [IDA]

plasma membrane [IDA]

CRISPR Database VEGA HGNC Alliance of Genome Resources OMIM Entrez Gene RefSeq UniprotKB Ensembl HPRD

Homo sapiens

PREY

SNW1

Bx42, NCOA-62, PRPF45, Prp45, SKIIP, SKIP

SNW domain containing 1

Cell Cycle - Mitotic Spindle Assembly Project

GO Process (19)

GO Function (9)

GO Component (7)

Gene Ontology Biological Process

Notch signaling pathway [TAS]

cellular response to retinoic acid [IDA]

gene expression [TAS]

intrinsic apoptotic signaling pathway in response to DNA damage by p53 class mediator [IMP]

mRNA splicing, via spliceosome [IC, IDA]

negative regulation of transcription from RNA polymerase II promoter [IDA]

negative regulation of transcription, DNA-templated [IDA]

positive regulation by host of viral transcription [IDA, IMP]

positive regulation of histone H3-K4 methylation [IMP]

positive regulation of mRNA splicing, via spliceosome [IMP]

positive regulation of neurogenesis [ISS]

positive regulation of transcription from RNA polymerase II promoter [IDA]

positive regulation of transforming growth factor beta receptor signaling pathway [IDA]

positive regulation of vitamin D receptor signaling pathway [IDA]

regulation of retinoic acid receptor signaling pathway [IDA]

regulation of transcription from RNA polymerase II promoter [TAS]

regulation of vitamin D receptor signaling pathway [IDA]

retinoic acid receptor signaling pathway [IDA]

transcription initiation from RNA polymerase II promoter [TAS]

Gene Ontology Molecular Function

Notch binding [IPI]
SMAD binding [IDA]
nuclear hormone receptor binding [IDA]
poly(A) RNA binding [IDA]
protein binding [IPI]
retinoic acid receptor binding [IDA]
transcription coactivator activity [IDA]
transcription corepressor activity [IDA]
vitamin D receptor binding [IDA]

Gene Ontology Cellular Component

SMAD3-SMAD4 protein complex [IDA]

catalytic step 2 spliceosome [IDA]

nuclear matrix [IDA]

nucleoplasm [IDA, TAS]

positive transcription elongation factor complex b [IDA]

spliceosomal complex [IDA]

CRISPR Database VEGA HGNC Alliance of Genome Resources OMIM Entrez Gene RefSeq UniprotKB Ensembl HPRD

Homo sapiens

Affinity Capture-MS

An interaction is inferred when a bait protein is affinity captured from cell extracts by either polyclonal antibody or epitope tag and the associated interaction partner is identified by mass spectrometric methods.

Publication

An unexpected role for BAG3 in regulating PARP1 ubiquitination in oxidative stress-related endothelial damage.

Zhang N, Zhang Y, Miao W, Shi C, Chen Z, Wu B, Zou Y, Ma Q, You S, Lu S, Huang X, Liu J, Xu J, Cao L, Sun Y

Oxidative stress-associated endothelial damage is the initiation factor of cardiovascular disease, and protein posttranslational modifications play critical roles in this process. Bcl-2-associated athanogene 3 (BAG3) is a molecular chaperone regulator of the BAG family, which interacts with various proteins and influences cell survival by activating multiple pathways. BAG3 undergoes posttranslational modifications; however, research evaluating BAG3 acetylation and its regulatory mechanism ... [more]

Redox Biol Dec. 01, 2021; 50();102238 [Pubmed: 35066290]

Throughput

Low Throughput

Curated By

BioGRID