BAIT
PRMT1
ANM1, HCP1, HRMT1L2, IR1B4
protein arginine methyltransferase 1
GO Process (9)
GO Function (8)
GO Component (3)
Gene Ontology Biological Process
- cell surface receptor signaling pathway [TAS]
- histone H4-R3 methylation [IDA]
- histone methylation [IDA]
- negative regulation of megakaryocyte differentiation [IDA]
- neuron projection development [IMP]
- peptidyl-arginine methylation [IDA]
- peptidyl-arginine methylation, to asymmetrical-dimethyl arginine [IBA]
- protein methylation [TAS]
- regulation of transcription, DNA-templated [IBA]
Gene Ontology Molecular Function- N-methyltransferase activity [IDA, IMP]
- histone methyltransferase activity [IDA]
- histone methyltransferase activity (H4-R3 specific) [IDA]
- identical protein binding [IPI]
- methyltransferase activity [TAS]
- poly(A) RNA binding [IDA]
- protein binding [IPI]
- protein-arginine omega-N asymmetric methyltransferase activity [IBA]
- N-methyltransferase activity [IDA, IMP]
- histone methyltransferase activity [IDA]
- histone methyltransferase activity (H4-R3 specific) [IDA]
- identical protein binding [IPI]
- methyltransferase activity [TAS]
- poly(A) RNA binding [IDA]
- protein binding [IPI]
- protein-arginine omega-N asymmetric methyltransferase activity [IBA]
Homo sapiens
PREY
ARHGEF2
GEF, GEF-H1, GEFH1, LFP40, P40, RP11-336K24.3
Rho/Rac guanine nucleotide exchange factor (GEF) 2
GO Process (24)
GO Function (8)
GO Component (8)
Gene Ontology Biological Process
- actin filament organization [IMP]
- apoptotic signaling pathway [TAS]
- cell morphogenesis [IMP]
- cellular hyperosmotic response [ISS]
- cellular response to muramyl dipeptide [IDA]
- cellular response to tumor necrosis factor [ISS]
- intracellular protein transport [NAS]
- negative regulation of extrinsic apoptotic signaling pathway via death domain receptors [ISS]
- negative regulation of intrinsic apoptotic signaling pathway in response to osmotic stress [ISS]
- negative regulation of microtubule depolymerization [IMP]
- negative regulation of necroptotic process [ISS]
- neurotrophin TRK receptor signaling pathway [TAS]
- positive regulation of NF-kappaB transcription factor activity [IDA]
- positive regulation of Rac GTPase activity [IDA]
- positive regulation of Rho GTPase activity [IDA]
- positive regulation of apoptotic process [TAS]
- positive regulation of interleukin-6 production [IDA]
- positive regulation of peptidyl-tyrosine phosphorylation [IDA]
- positive regulation of transcription from RNA polymerase II promoter [IDA]
- positive regulation of tumor necrosis factor production [IDA]
- regulation of Rho protein signal transduction [NAS]
- regulation of cell proliferation [TAS]
- regulation of small GTPase mediated signal transduction [TAS]
- small GTPase mediated signal transduction [TAS]
Gene Ontology Molecular Function
Gene Ontology Cellular Component
Homo sapiens
Affinity Capture-MS
An interaction is inferred when a bait protein is affinity captured from cell extracts by either polyclonal antibody or epitope tag and the associated interaction partner is identified by mass spectrometric methods.
Publication
Arginine methylation and ubiquitylation crosstalk controls DNA end-resection and homologous recombination repair.
Cross-talk between distinct protein post-translational modifications is critical for an effective DNA damage response. Arginine methylation plays an important role in maintaining genome stability, but how this modification integrates with other enzymatic activities is largely unknown. Here, we identify the deubiquitylating enzyme USP11 as a previously uncharacterised PRMT1 substrate, and demonstrate that the methylation of USP11 promotes DNA end-resection and ... [more]
Nat Commun Dec. 02, 2020; 12(1);6313 [Pubmed: 34728620]
Throughput
- High Throughput
Additional Notes
- Affinity Capture-MS was carried out to identify high confidence protein-protein interactors
Curated By
- BioGRID