BAIT
PRMT1
ANM1, HCP1, HRMT1L2, IR1B4
protein arginine methyltransferase 1
GO Process (9)
GO Function (8)
GO Component (3)
Gene Ontology Biological Process
- cell surface receptor signaling pathway [TAS]
- histone H4-R3 methylation [IDA]
- histone methylation [IDA]
- negative regulation of megakaryocyte differentiation [IDA]
- neuron projection development [IMP]
- peptidyl-arginine methylation [IDA]
- peptidyl-arginine methylation, to asymmetrical-dimethyl arginine [IBA]
- protein methylation [TAS]
- regulation of transcription, DNA-templated [IBA]
Gene Ontology Molecular Function- N-methyltransferase activity [IDA, IMP]
- histone methyltransferase activity [IDA]
- histone methyltransferase activity (H4-R3 specific) [IDA]
- identical protein binding [IPI]
- methyltransferase activity [TAS]
- poly(A) RNA binding [IDA]
- protein binding [IPI]
- protein-arginine omega-N asymmetric methyltransferase activity [IBA]
- N-methyltransferase activity [IDA, IMP]
- histone methyltransferase activity [IDA]
- histone methyltransferase activity (H4-R3 specific) [IDA]
- identical protein binding [IPI]
- methyltransferase activity [TAS]
- poly(A) RNA binding [IDA]
- protein binding [IPI]
- protein-arginine omega-N asymmetric methyltransferase activity [IBA]
Homo sapiens
PREY
MYO1C
MMI-beta, MMIb, NMI, myr2
myosin IC
GO Process (10)
GO Function (2)
GO Component (14)
Gene Ontology Biological Process
- Fc-gamma receptor signaling pathway involved in phagocytosis [TAS]
- innate immune response [TAS]
- membrane organization [TAS]
- positive regulation of cell migration [IMP]
- positive regulation of cell migration by vascular endothelial growth factor signaling pathway [IMP]
- positive regulation of protein targeting to membrane [IMP]
- positive regulation of vascular endothelial growth factor signaling pathway [IMP]
- protein targeting [IDA]
- protein targeting to membrane [IDA]
- regulation of tight junction assembly [IMP]
Gene Ontology Molecular Function
Gene Ontology Cellular Component
- basal plasma membrane [IDA]
- cytoplasm [IDA]
- cytosol [TAS]
- extracellular vesicular exosome [IDA]
- filamentous actin [IDA]
- lateral plasma membrane [IDA]
- membrane [IDA]
- membrane raft [IDA]
- microvillus [IDA]
- mitochondrion [IDA]
- nucleoplasm [IDA]
- plasma membrane [IDA]
- stress fiber [IDA]
- unconventional myosin complex [TAS]
Homo sapiens
Affinity Capture-MS
An interaction is inferred when a bait protein is affinity captured from cell extracts by either polyclonal antibody or epitope tag and the associated interaction partner is identified by mass spectrometric methods.
Publication
Arginine methylation and ubiquitylation crosstalk controls DNA end-resection and homologous recombination repair.
Cross-talk between distinct protein post-translational modifications is critical for an effective DNA damage response. Arginine methylation plays an important role in maintaining genome stability, but how this modification integrates with other enzymatic activities is largely unknown. Here, we identify the deubiquitylating enzyme USP11 as a previously uncharacterised PRMT1 substrate, and demonstrate that the methylation of USP11 promotes DNA end-resection and ... [more]
Nat Commun Dec. 02, 2020; 12(1);6313 [Pubmed: 34728620]
Throughput
- High Throughput
Additional Notes
- Affinity Capture-MS was carried out to identify high confidence protein-protein interactors
Curated By
- BioGRID