BAIT
PDS5
L000003047, YMR076C
Cohesion maintenance factor; involved in sister chromatid condensation and cohesion; colocalizes with cohesin on chromosomes; performs its cohesin maintenance function in pre-anaphase cells by protecting the integrity of the cohesion complex; also required during meiosis; relocalizes to the cytosol in response to hypoxia
GO Process (5)
GO Function (1)
GO Component (5)
Gene Ontology Biological Process
Gene Ontology Molecular Function
Gene Ontology Cellular Component
Saccharomyces cerevisiae (S288c)
PREY
MCK1
CMS1, YPK1, serine/threonine/tyrosine protein kinase MCK1, L000001036, S000029094, L000000369, YNL307C
Dual-specificity ser/thr and tyrosine protein kinase; roles in chromosome segregation, meiotic entry, genome stability, phosphorylation-dependent protein degradation (Rcn1p and Cdc6p), inhibition of protein kinase A, transcriptional regulation, inhibition of RNA pol III, calcium stress and inhibition of Clb2p-Cdc28p after nuclear division; MCK1 has a paralog, YGK3, that arose from the whole genome duplication
GO Process (9)
GO Function (5)
GO Component (0)
Gene Ontology Biological Process
- ascospore formation [IMP]
- cellular response to heat [IMP]
- cellular response to salt stress [IMP]
- double-strand break repair via nonhomologous end joining [IMP]
- meiotic nuclear division [IMP]
- mitotic sister chromatid segregation [IGI, IMP]
- peptidyl-serine phosphorylation [IDA]
- protein phosphorylation [IDA]
- protein phosphorylation involved in cellular protein catabolic process [IGI, IMP]
Gene Ontology Molecular Function
Saccharomyces cerevisiae (S288c)
Affinity Capture-MS
An interaction is inferred when a bait protein is affinity captured from cell extracts by either polyclonal antibody or epitope tag and the associated interaction partner is identified by mass spectrometric methods.
Publication
The ubiquitin-proteasome system regulates meiotic chromosome organization.
Meiotic crossover (CO) recombination is tightly regulated by chromosome architecture to ensure faithful chromosome segregation and to reshuffle alleles between parental chromosomes for genetic diversity of progeny. However, regulation of the meiotic chromosome loop/axis organization is poorly understood. Here, we identify a molecular pathway for axis length regulation. We show that the cohesin regulator Pds5 can interact with proteasomes. Meiosis-specific ... [more]
Proc Natl Acad Sci U S A Dec. 26, 2021; 119(17);e2106902119 [Pubmed: 35439061]
Throughput
- High Throughput
Curated By
- BioGRID