BAIT
GJA1
AVSD3, CMDR, CX43, GJAL, HLHS1, HSS, ODDD
gap junction protein, alpha 1, 43kDa
GO Process (11)
GO Function (4)
GO Component (11)
Gene Ontology Biological Process
- atrial cardiac muscle cell action potential [TAS]
- cell communication by electrical coupling [IDA]
- cell-cell signaling [TAS]
- gap junction assembly [TAS]
- heart development [TAS]
- ion transmembrane transport [TAS]
- membrane organization [TAS]
- muscle contraction [TAS]
- positive regulation of I-kappaB kinase/NF-kappaB signaling [IMP]
- signal transduction [IMP]
- transport [TAS]
Gene Ontology Molecular Function
Gene Ontology Cellular Component
- Golgi apparatus [ISS]
- Golgi membrane [TAS]
- Golgi-associated vesicle membrane [TAS]
- endoplasmic reticulum membrane [TAS]
- extracellular vesicular exosome [IDA]
- focal adhesion [IDA]
- gap junction [IDA, ISS]
- integral component of plasma membrane [TAS]
- intercalated disc [IDA, ISS]
- membrane raft [ISS]
- plasma membrane [ISS, TAS]
Homo sapiens
PREY
PPM1A
PP2C-ALPHA, PP2CA, PP2Calpha
protein phosphatase, Mg2+/Mn2+ dependent, 1A
GO Process (19)
GO Function (5)
GO Component (4)
Gene Ontology Biological Process
- N-terminal protein myristoylation [ISS]
- Wnt signaling pathway [IDA]
- cell cycle arrest [TAS]
- dephosphorylation [IDA]
- gene expression [TAS]
- insulin receptor signaling pathway [TAS]
- negative regulation of I-kappaB kinase/NF-kappaB signaling [IMP]
- negative regulation of NF-kappaB import into nucleus [IMP]
- negative regulation of SMAD protein complex assembly [IDA]
- negative regulation of transcription from RNA polymerase II promoter [TAS]
- negative regulation of transforming growth factor beta receptor signaling pathway [IDA]
- peptidyl-threonine dephosphorylation [IDA]
- positive regulation of I-kappaB kinase/NF-kappaB signaling [IMP]
- positive regulation of Wnt signaling pathway [IDA]
- positive regulation of transcription, DNA-templated [IDA]
- protein dephosphorylation [IMP]
- transcription initiation from RNA polymerase II promoter [TAS]
- transcription, DNA-templated [TAS]
- transforming growth factor beta receptor signaling pathway [TAS]
Gene Ontology Molecular Function
Homo sapiens
Affinity Capture-MS
An interaction is inferred when a bait protein is affinity captured from cell extracts by either polyclonal antibody or epitope tag and the associated interaction partner is identified by mass spectrometric methods.
Publication
The Effect of the NF?B-USP9X-Cx43 Axis on the Dynamic Balance of Bone Formation/Degradation during Ossification of the Posterior Longitudinal Ligament of the Cervical Spine.
Connexin 43- (Cx43-) mediated nuclear factor kappa-light-chain-enhancer of activated B cell (NF-?B) signaling has been found involved in the ossification of the posterior longitudinal ligament (OPLL). However, the underlying mechanism how OPLL is regulated has not been elucidated. In the present study, primary ligament fibroblast were isolated; immunoprecipitation (IP) and liquid chromatography-mass spectrometry (LC-MS) assays were applied to identify potential ... [more]
Oxid Med Cell Longev Apr. 09, 2022; 2022();1604932 [Pubmed: 35391932]
Throughput
- Low Throughput
Curated By
- BioGRID