BAIT

PDE2

SRA5, 3',5'-cyclic-nucleotide phosphodiesterase PDE2, L000002046, YOR360C
High-affinity cyclic AMP phosphodiesterase; component of the cAMP-dependent protein kinase signaling system, protects the cell from extracellular cAMP, contains readthrough motif surrounding termination codon
GO Process (1)
GO Function (1)
GO Component (2)

Gene Ontology Biological Process

Gene Ontology Molecular Function

Gene Ontology Cellular Component

Saccharomyces cerevisiae (S288c)
PREY

PBS2

HOG4, SFS4, SSK4, mitogen-activated protein kinase kinase PBS2, L000001346, L000001874, YJL128C
MAP kinase kinase of the HOG signaling pathway; activated under severe osmotic stress; mitophagy-specific regulator; plays a role in regulating Ty1 transposition
Kinome Project (Sc)
Saccharomyces cerevisiae (S288c)

Phenotypic Suppression

A genetic interaction is inferred when mutation or over expression of one gene results in suppression of any phenotype (other than lethality/growth defect) associated with mutation or over expression of another gene.

Publication

Crosstalk between protein kinase A and the HOG pathway under impaired biosynthesis of complex sphingolipids in budding yeast.

Urita A, Ishibashi Y, Kawaguchi R, Yanase Y, Tani M

Complex sphingolipids are important components of the lipid bilayer of budding yeast Saccharomyces cerevisiae, and a defect of the biosynthesis causes widespread cellular dysfunction. In this study, we found that mutations causing upregulation of the cAMP/protein kinase A (PKA) pathway cause hypersensitivity to the defect of complex sphingolipid biosynthesis caused by repression of AUR1 encoding inositol phosphorylceramide synthase, whereas loss ... [more]

FEBS J Dec. 01, 2021; 289(3);766-786 [Pubmed: 34492172]

Throughput

  • Low Throughput

Ontology Terms

  • protein/peptide accumulation (APO:0000149)

Additional Notes

  • The deletion of IRA2 or PDE2 caused a significant decrease in the GRE2 promoter activity under the AUR1-repressive conditions, and the decrease was cancelled out by the overexpression of PBS2

Related interactions

InteractionExperimental Evidence CodeDatasetThroughputScoreCurated ByNotes
PDE2 PBS2
Negative Genetic
Negative Genetic

Mutations/deletions in separate genes, each of which alone causes a minimal phenotype, but when combined in the same cell results in a more severe fitness defect or lethality under a given condition. This term is reserved for high or low throughput studies with scores.

High-0.1205BioGRID
2187997

Curated By

  • BioGRID