BAIT
CUL3
CUL-3, PHA2E
cullin 3
GO Process (20)
GO Function (3)
GO Component (5)
Gene Ontology Biological Process
- COPII vesicle coating [IMP]
- ER to Golgi vesicle-mediated transport [IDA]
- G1/S transition of mitotic cell cycle [TAS]
- cell cycle arrest [TAS]
- cell migration [IMP]
- embryonic cleavage [ISS]
- integrin-mediated signaling pathway [ISS]
- intrinsic apoptotic signaling pathway [TAS]
- mitotic metaphase plate congression [IMP]
- negative regulation of Rho protein signal transduction [IMP]
- negative regulation of cyclin-dependent protein serine/threonine kinase by cyclin degradation [IDA]
- positive regulation of cell proliferation [TAS]
- positive regulation of cytokinesis [IMP]
- positive regulation of mitotic metaphase/anaphase transition [IMP]
- proteasome-mediated ubiquitin-dependent protein catabolic process [IDA]
- protein monoubiquitination [IDA]
- protein polyubiquitination [IDA]
- protein ubiquitination [IDA]
- stem cell division [ISS]
- stress fiber assembly [IMP]
Gene Ontology Molecular Function
Gene Ontology Cellular Component
Homo sapiens
PREY
SLIT2
SLIL3, Slit-2
slit homolog 2 (Drosophila)
GO Process (37)
GO Function (9)
GO Component (7)
Gene Ontology Biological Process
- Roundabout signaling pathway [IC, IMP]
- apoptotic process involved in luteolysis [IEP]
- axon extension involved in axon guidance [IDA]
- axon guidance [IDA, TAS]
- branching morphogenesis of an epithelial tube [IDA, IMP]
- cell migration involved in sprouting angiogenesis [IMP]
- cellular response to heparin [IDA]
- cellular response to hormone stimulus [IEP]
- chemorepulsion involved in embryonic olfactory bulb interneuron precursor migration [IDA]
- chemorepulsion involved in postnatal olfactory bulb interneuron migration [IDA]
- corticospinal neuron axon guidance through spinal cord [IMP]
- induction of negative chemotaxis [IDA]
- motor neuron axon guidance [IDA]
- negative chemotaxis [IDA, IMP]
- negative regulation of actin filament polymerization [IDA]
- negative regulation of catalytic activity [IDA]
- negative regulation of cell growth [IMP]
- negative regulation of cell migration [IDA, IMP]
- negative regulation of cellular response to growth factor stimulus [IDA]
- negative regulation of chemokine-mediated signaling pathway [IMP]
- negative regulation of endothelial cell migration [IDA]
- negative regulation of lamellipodium assembly [IDA]
- negative regulation of leukocyte chemotaxis [IDA]
- negative regulation of monocyte chemotaxis [ISS]
- negative regulation of mononuclear cell migration [IDA]
- negative regulation of neutrophil chemotaxis [IDA]
- negative regulation of protein phosphorylation [IDA]
- negative regulation of retinal ganglion cell axon guidance [IDA]
- negative regulation of small GTPase mediated signal transduction [IDA]
- negative regulation of smooth muscle cell chemotaxis [IDA]
- negative regulation of smooth muscle cell migration [IDA]
- negative regulation of vascular permeability [IDA]
- positive regulation of apoptotic process [IMP]
- positive regulation of axonogenesis [TAS]
- response to cortisol [IEP]
- retinal ganglion cell axon guidance [IDA]
- ureteric bud development [IMP]
Gene Ontology Molecular Function
Gene Ontology Cellular Component
Homo sapiens
Affinity Capture-MS
An interaction is inferred when a bait protein is affinity captured from cell extracts by either polyclonal antibody or epitope tag and the associated interaction partner is identified by mass spectrometric methods.
Publication
Cullin 3 Exon 9 Deletion in Familial Hyperkalemic Hypertension Impairs Cullin3-Ring-E3 Ligase (CRL3) Dynamic Regulation and Cycling.
Cullin 3 (CUL3) is the scaffold of Cullin3 Ring E3-ligases (CRL3s), which use various BTB-adaptor proteins to ubiquitinate numerous substrates targeting their proteasomal degradation. CUL3 mutations, responsible for a severe form of familial hyperkalemia and hypertension (FHHt), all result in a deletion of exon 9 (amino-acids 403-459) (CUL3-?9). Surprisingly, while CUL3-?9 is hyperneddylated, a post-translational modification that typically activates CRL ... [more]
Int J Mol Sci May. 05, 2022; 23(9); [Pubmed: 35563538]
Throughput
- High Throughput
Curated By
- BioGRID