BAIT
CUL3
CUL-3, PHA2E
cullin 3
GO Process (20)
GO Function (3)
GO Component (5)
Gene Ontology Biological Process
- COPII vesicle coating [IMP]
- ER to Golgi vesicle-mediated transport [IDA]
- G1/S transition of mitotic cell cycle [TAS]
- cell cycle arrest [TAS]
- cell migration [IMP]
- embryonic cleavage [ISS]
- integrin-mediated signaling pathway [ISS]
- intrinsic apoptotic signaling pathway [TAS]
- mitotic metaphase plate congression [IMP]
- negative regulation of Rho protein signal transduction [IMP]
- negative regulation of cyclin-dependent protein serine/threonine kinase by cyclin degradation [IDA]
- positive regulation of cell proliferation [TAS]
- positive regulation of cytokinesis [IMP]
- positive regulation of mitotic metaphase/anaphase transition [IMP]
- proteasome-mediated ubiquitin-dependent protein catabolic process [IDA]
- protein monoubiquitination [IDA]
- protein polyubiquitination [IDA]
- protein ubiquitination [IDA]
- stem cell division [ISS]
- stress fiber assembly [IMP]
Gene Ontology Molecular Function
Gene Ontology Cellular Component
Homo sapiens
PREY
PHF8
JHDM1F, MRXSSD, ZNF422, RP13-444K19.2
PHD finger protein 8
GO Process (10)
GO Function (11)
GO Component (4)
Gene Ontology Biological Process
- G1/S transition of mitotic cell cycle [IMP]
- brain development [ISS]
- histone H3-K27 demethylation [IDA]
- histone H3-K36 demethylation [IDA]
- histone H3-K9 demethylation [IDA]
- histone H4-K20 demethylation [IDA]
- mitotic cell cycle [TAS]
- negative regulation of chromatin silencing at rDNA [IDA]
- positive regulation of transcription from RNA polymerase I promoter [IDA]
- positive regulation of transcription, DNA-templated [IDA, IMP]
Gene Ontology Molecular Function- chromatin binding [IDA]
- histone demethylase activity [IDA]
- histone demethylase activity (H3-K27 specific) [IDA]
- histone demethylase activity (H3-K36 specific) [IDA]
- histone demethylase activity (H3-K9 specific) [IDA]
- histone demethylase activity (H4-K20 specific) [IDA]
- iron ion binding [IDA]
- methylated histone binding [IDA]
- oxidoreductase activity, acting on paired donors, with incorporation or reduction of molecular oxygen, 2-oxoglutarate as one donor, and incorporation of one atom each of oxygen into both donors [IDA]
- protein binding [IPI]
- zinc ion binding [IDA]
- chromatin binding [IDA]
- histone demethylase activity [IDA]
- histone demethylase activity (H3-K27 specific) [IDA]
- histone demethylase activity (H3-K36 specific) [IDA]
- histone demethylase activity (H3-K9 specific) [IDA]
- histone demethylase activity (H4-K20 specific) [IDA]
- iron ion binding [IDA]
- methylated histone binding [IDA]
- oxidoreductase activity, acting on paired donors, with incorporation or reduction of molecular oxygen, 2-oxoglutarate as one donor, and incorporation of one atom each of oxygen into both donors [IDA]
- protein binding [IPI]
- zinc ion binding [IDA]
Gene Ontology Cellular Component
Homo sapiens
Affinity Capture-MS
An interaction is inferred when a bait protein is affinity captured from cell extracts by either polyclonal antibody or epitope tag and the associated interaction partner is identified by mass spectrometric methods.
Publication
Cullin 3 Exon 9 Deletion in Familial Hyperkalemic Hypertension Impairs Cullin3-Ring-E3 Ligase (CRL3) Dynamic Regulation and Cycling.
Cullin 3 (CUL3) is the scaffold of Cullin3 Ring E3-ligases (CRL3s), which use various BTB-adaptor proteins to ubiquitinate numerous substrates targeting their proteasomal degradation. CUL3 mutations, responsible for a severe form of familial hyperkalemia and hypertension (FHHt), all result in a deletion of exon 9 (amino-acids 403-459) (CUL3-?9). Surprisingly, while CUL3-?9 is hyperneddylated, a post-translational modification that typically activates CRL ... [more]
Int J Mol Sci May. 05, 2022; 23(9); [Pubmed: 35563538]
Throughput
- High Throughput
Curated By
- BioGRID